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Volume 19, Number 10—October 2013

Research

Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2

Na Li, Lihua Xiao, Vitaliano A. Cama, Ynes Ortega, Robert H. Gilman, Meijin Guo, and Yaoyu FengComments to Author 
Author affiliations: East China University of Science and Technology, Shanghai, China (N. Li, M. Guo, Y. Feng); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (N. Li, L. Xiao, V.A. Cama); University of Georgia, Griffin, Georgia, USA (Y. Ortega); Johns Hopkins University, Baltimore, Maryland, USA (R.H. Gilman)

Main Article

Table 3

Pairwise interlocus linkage disequilibrium and recombination analysis of concatenated multilocus sequences from various subtypes of Cryptosporidium hominis*

Population No. samples No. segregating sites analyzed No. pairwise comparisons No. significant pairwise comparisons† Zns |D'| LD Estimate of R/gene Minimum no. recombination events
Including gp60‡
All 53 362 47,895 25,904 (8,714) 0.2711 Y = 0.9289 – 0.0299X Incomplete 5.0 33
IaA13R8(7) 10 20 190 0 0.7581 Y = 1.0000 + 0.0000X Complete 0.001 0
IbA10G2 26 31 465 160 (140) 0.3660 Y = 0.9342 + 0.0001X Incomplete 0.3 4
IdA10 6 14 91 0 1.0000 Y = 1.0000 + 0.0000X Complete 0.001 0
IdA20 5 3 3 0 0.3750 Y = 1.0000 + 0.0000X Complete 0.001 0
IeA11G3T3 6 19 171 0 1.0000 Y = 1.0000 + 0.0000X Complete 0.001 0
Excluding gp60§
All 53 65 2080 921 (333) 0.2184 Y = 0.7886 + 0.0051X Incomplete 1.8 6
IaA13R8(7) 10 20 190 0 0.7581 Y = 1.0000 + 0.0000X Complete 0.001 0
IbA10G2 26 31 465 160 (140) 0.3660 Y = 0.9302 + 0.0010X Incomplete 0.3 4
IdA10 6 14 91 0 1.0000 Y = 1.0000 + 0.0000X Complete 0.001 0
IdA20 5 3 3 0 0.3750 Y = 1.0000 + 0.0000X Complete 0.001 0
IeA11G3T3 6 19 171 0 1.0000 Y = 1.0000 + 0.0000X Complete 0.001 0

*Zns, interlocus genetic association; |D'|, linkage disequilibrium (LD) value, where Y is LD value and X is nucleotide distance in kilobases; gp 60, 60-kDa glycoprotein gene.
†By Fisher exact test (after Bonferroni correction).
‡Based on concatenated multilocus gene sequence of all loci (15,717 bp).
§Based on concatenated multilocus gene sequence of all loci excluding gp60 (14,768 bp).

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