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Volume 19, Number 10—October 2013

Dispatch

Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus

Chao Qiu1, Yang Huang1, Anli Zhang1, Di Tian1, Yanmin Wan1, Xiaoling Zhang, Wanju Zhang, Zhiyong Zhang, Zhenghong Yuan, Yunwen Hu, Xiaoyan Zhang, and Jianqing XuComments to Author 
Author affiliations: Shanghai Public Health Clinical Center, Shanghai, China (C. Qiu, A. Zhang, D. Tian, Y. Wan, Xiaoling Zhang, W. Zhang, Z. Zhang, Z. Yuan, Y. Hu, Xiaoyan Zhang, J. Xu); Fudan University, Shanghai (C. Qiu, Y. Huang, A. Zhang, Z. Yuan, Xiaoyan Zhang, J. Xu); Chinese Center for Disease Control and Prevention, Beijing, China (Xiaoyan Zhang, J. Xu)

Main Article

Figure

Correlation between conventional hemagluttination (HI) titer and 50% inhibitory concentration (IC50) titer of pseudovirus-based assay for diagnosing influenza A(H7N9) virus infection. Correlation between the IC50 titer of the pseudovirus-based neutralization assay and the titer of conventional HI assay, tested with 14 serum samples collected >10 days after symptom onset from patients with real-time RT-PCR–confirmed 2013 influenza A(H7N9) infection (○) and 50 control samples (△, Spearman r = 0

Figure. . Correlation between conventional hemagluttination (HI) titer and 50% inhibitory concentration (IC50) titer of pseudovirus-based assay for diagnosing influenza A(H7N9) virus infection. Correlation between the IC50 titer of the pseudovirus-based neutralization assay and the titer of conventional HI assay, tested with 14 serum samples collected >10 days after symptom onset from patients with real-time RT-PCR–confirmed 2013 influenza A(H7N9) infection (○) and 50 control samples (△, Spearman r = 0.88, p<0.0001, n = 64). To display the information from all the samples, overlapped markers were shifted on the x- and/or y-axis with small incremental units.

Main Article

1These authors contributed equally to this article.

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