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Volume 19, Number 10—October 2013

Dispatch

Subclinical Avian Influenza A(H5N1) Virus Infection in Human, Vietnam

Mai Quynh LeComments to Author , Peter Horby, Annette Fox, Hien Tran Nguyen, Hang Khanh Le Nguyen, Phuong Mai Vu Hoang, Khanh Cong Nguyen, Menno D. de Jong, Rienk E. Jeeninga, H. Rogier van Doorn, Jeremy Farrar, and Heiman F.L. Wertheim
Author affiliations: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (M.Q.Le, H.T. Nguyen, H.K.L. Nguyen, P.M.V. Hoang, K.C. Nguyen); Wellcome Trust Major Overseas Programme, Hanoi and Ho Chi Minh City, Vietnam (P. Horby, A. Fox, M.D. de Jong, H.R. van Doorn, J. Farrar, H.F.L. Wertheim); Centre for Tropical Medicine, Oxford, United Kingdom (P. Horby, A. Fox, H.R. van Doorn, J. Farrar, H.F.L. Wertheim); Academic Medical Center, Amsterdam, the Netherlands (M.D. de Jong, R.E. Jeeninga)

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Table 2

Amino acid changes detected in first passage of full-genome sequence analysis of influenza A(H5N1) virus isolate from subclinical human infection, Vietnam

Gene and mutation
Mutation frequency, %
Polybasic 2, n = 112
S107N 15
I261T 2
K312R 15
Nucleoprotein, n = 125
I33V 48
H52Y 50
R77K 45
T395N 49
Polymerase, n = 51
A20T 12
D27S 12
V63A 29
T85T 33
K142R 12
Y241C 45
Q259P 33
L261M 29
A263T 43
D272E 12
V323I 2
E352D 12
R353K 29
R391K 29
S400P 35
A404S 29
D547N 2
A552T 37
N614T 29
G631S 29
S648C 2
L711I 2
Polybasic 1, n = 129
K54E 22
S158N 49
T182I 2
N314S 2
D383E 30
L384I 7
I525V 9
S633N 2
K635R 19
Hemagglutinin, n = 244
T9A 49
L82M 36
S139T 6
S152P 36
D199N 2
F455Y 1
K461R 8
Neuraminidase, n = 177
I8V 16
V13I 27
I16V 21
A46T 14
T64A 1
A66S 1
H106N 1
M107L 23
V143I 10
T168I 2
G200R 49
A212T 1
S265A 36
T312E 1
M318V 26
I326V 21
N346H 13
V369M 19
Nonstructural 1, n = 145
S73P 11
D87E 6
M118I 28
V123I 28
E148K 1
S166G 25
M217L 1
T220A 6

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