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Volume 19, Number 11—November 2013

CME ACTIVITY - Research

Possible Association between Obesity and Clostridium difficile Infection

Jason Leung, Bob Burke, Dale Ford, Gail Garvin, Cathy Korn, Carol Sulis, and Nahid BhadeliaComments to Author 
Author affiliations: University of Michigan Hospital, Ann Arbor, Michigan, USA (Leung, J.); Boston Medical Center, Boston (B. Burke, D. Ford, G. Garvin, C. Korn, C. Sulis, N. Bhadelia)

Main Article

Table 1

Patient characteristics associated with cases of community onset, community-onset health care–associated, and health care onset cases of Clostridium difficile infections

CharacteristicCommunity onset n = 59 Community-onset health care–associated n = 32 Health care onset n = 41 p value
Demographic traits
Mean age [range]57.8 [22–96]63.7 [23–95]61.6 [21–96]0.31*
Male sex, no. (%)
27 (46)
10 (31)
23 (56)
0.106
Medication use, no. (%)
Prior antibiotic use31 (52.5)11 (34.4)33 (80)<0.001
Antiulcer medication
24 (41)
18 (56)
19 (46)
0.363
Physical status/illness, no. (%)
Obese (body mass index>30) 20 (34)4 (13)13 (32)0.078
Immunocompromised†14 (24)11 (34)11 (27)0.551
Diabetes14 (24)9 (28)7 (17)0.519
Irritable bowel disease
10 (17)
1 (3)
1 (2)
0.018
Required inpatient admission, no. (%)41 (69)29 (91)39 (95)0.002
Average days stayed7.78.218.6<0.001
Required intensive care unit stay11 (27)8 (28)24 (61)0.002

*P value for 1-way analysis of variance.
†Immunocomprised group included all malignancies, innate and acquired immune conditions such as HIV/AIDS, and congenital immune defects. This group excluded comorbidities listed separately.

Main Article

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