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Volume 19, Number 12—December 2013

Research

Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

Juan-María TorresComments to Author , Joaquín Castilla, Belén Pintado, Alfonso Gutiérrez-Adan, Olivier Andréoletti, Patricia Aguilar-Calvo, Ana-Isabel Arroba, Beatriz Parra-Arrondo, Isidro Ferrer, Jorge Manzanares, and Juan-Carlos Espinosa
Author affiliations: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain (J.-M. Torres, J. Castilla, B. Pintado, A. Gutiérrez-Adán P. Aguilar-Calvo, A.-I. Arroba, B. Parra-Arrondo, J.-C. Espinosa); Basque Foundation for Science, Bilbao, Spain (J. Castilla); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti); Hospitalet de Llobregat, Barcelona, Spain (I. Ferrer); Universidad Miguel Hernandez, Sant Joan d´Alacant, Spain (J. Manzanares)

Main Article

Figure 2

Comparison between homozygous bovine prion protein (BoPrP)-Tg110+/+ control mice (panels A–D) and hemizygous 113LBoPrP-Tg037+/− mice with end-stage disease (panels E–H) in parietal cortex (panels A and E), CA1 region of the hipocampus (panels B and F), dentate gyrus (panels C and G), and medial thalamus (panels D and H). Severe spongiosis is seen in the cerebral cortex, hilus ofdentate gyrus, and medial thalamus, but not in the CA1 area of the hippocampus and granule cell layer of the dentate gy

Figure 2. . . Comparison between homozygous bovine prion protein (BoPrP)-Tg110+/+ control mice (panels A–D) and hemizygous 113LBoPrP-Tg037+/− mice with end-stage disease (panels E–H) in parietal cortex (panels A and E), CA1 region of the hipocampus (panels B and F), dentate gyrus (panels C and G), and medial thalamus (panels D and H). Severe spongiosis is seen in the cerebral cortex, hilus ofdentate gyrus, and medial thalamus, but not in the CA1 area of the hippocampus and granule cell layer of the dentate gyrus. 113L, leucine substitution at codon 113. Paraffin-embedded sections were stained with hematoxylin and eosin. Scale bar in panel H = 25 μm.

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