Spontaneous Generation of Infectious Prion Disease in Transgenic Mice
Figure 6. . . Vacuolar lesion profile in brains from BoPrP-Tg110 mice inoculated with bovine spongiform encephalopathy (BSE)-C (black circles, n = 6 animals), BSE-H (black triangles, n = 6 animals), BSE-L (black squares, n = 5 animals), 113L-BSE second passage (black squares, n = 5 animals), and 113L-BSE third passage (open diamonds, n = 5 animals) prions. Lesion scoring was conducted for 9 areas of gray matter (G) and 3 areas of white matter (W) in mouse brains. G1, dorsal medulla; G2, cerebellar cortex; G3, superior colliculus; G4, hypothalamus; G5, medial thalamus; G6, hippocampus; G7, septum; G8, medial cerebral cortex at the level of the thalamus; G9, medial cerebral cortex at the level of the septum (G9); W1, cerebellum; W2, mesencephalic tegmentum; W3, pyramidel tract. BoPrP, bovine prion protein; 113L, leucine substitution at codon 113. Error bars indicate SE.