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Volume 19, Number 2—February 2013

CME ACTIVITY

Eastern Equine Encephalitis in Children, Massachusetts and New Hampshire,USA, 1970–2010

Michael A. Silverman, John Misasi, Sandra Smole, Henry A. Feldman, Adam B. Cohen, Sandro Santagata, Michael McManus, and Asim A. AhmedComments to Author 
Author affiliations: Author affiliations: Children's Hospital Boston, Boston, Massachusetts, USA (M.A. Silverman, J. Misasi, H.A. Feldman, S. Santagata, M. McManus, A.A. Ahmed); Department of Public Health, Boston (S. Smole); Massachusetts General Hospital, Boston (A.B. Cohen); Brigham and Women’s Hospital, Boston (S. Santagata)

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Table 1

Clinical features of and diagnostic studies for 15 children with eastern equine encephalitis, Massachusetts and New Hampshire, 1970–2010*

Patient no.Admitted to hospitalAge, y/sexProdome length, dBlood leukocytes, 103 cells/μLCSF leukocytes, cells/μLCSF protein, mg/dLICP checkedTreatmentOutcome at dischargeStatus at follow-up
11970 Aug 0.5/M228.030064NoAEDs, mannitolSevere disabilityStable
21974 Aug1.2/M2NoDeath
31982 Sep0.8/M117.11166NoVidarabine, acyclovir, AEDs, dexamethasoneSevere disabilityImproved
41982 Sep14.7/F217.31,00480YesAEDs, mannitolSevere disabilityImproved
51983 Aug11.2/M321.072061NoMannitolFull recovery
61984 Aug6.5/F021.01,38446YesAcyclovir, AEDs, pentobarbitol coma, dexamethasone, mannitolSevere disabilityImproved
71995 Aug0.5/M413.645173NoAcyclovir, AEDs, IVIG, dexamethasone, cyclophosphamideSevere disability
82000 Sep4.0/F522.725833NoAcylovir, AEDsFull recovery
92001 Aug3.9/F512.01,20054NoAcylovir, AEDsMild to moderate
disabilityFully recovered
102004 Aug13.1/M08.486084NoAcylovir, AEDs dexamethasone, mannitol, 3% salineDeath
112004 Oct11.5/F816.561673NoAcylovirFull recovery
122005 Aug5.3/F234.884773NoAcylovir, AEDs, 3% salineDeath
132006 Aug 9.9/M223.01,08581YesAcylovir, AEDs, pentobarbitol coma, interferon α-2b, dexamethasone, IVIG, 3% salineDeath
142007 Aug13.3/M620.4888124NoAcylovir, AEDs, IVIG, 3% salineMild to moderate
disabilityStable
152009 Sep3.5/F517.825839NoAcylovir, AEDs, dexamethasoneFull recovery

*CSF, cerebrospinal fluid; ICP, intracranial pressure; AEDs, anti-epileptic drugs (phenobarbital, phenytoin, fosphenytoin, carbamazepine, oxcarbazepine, lorazepam, levetiracetam); –, patient died or did not return for follow-up; IVIG, intravenous immunoglobulin

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