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Volume 19, Number 2—February 2013

CME ACTIVITY

Eastern Equine Encephalitis in Children, Massachusetts and New Hampshire,USA, 1970–2010

Michael A. Silverman, John Misasi, Sandra Smole, Henry A. Feldman, Adam B. Cohen, Sandro Santagata, Michael McManus, and Asim A. AhmedComments to Author 
Author affiliations: Author affiliations: Children's Hospital Boston, Boston, Massachusetts, USA (M.A. Silverman, J. Misasi, H.A. Feldman, S. Santagata, M. McManus, A.A. Ahmed); Department of Public Health, Boston (S. Smole); Massachusetts General Hospital, Boston (A.B. Cohen); Brigham and Women’s Hospital, Boston (S. Santagata)

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Table 5

Colocalization of lesions, virus, and brain inflammation in 2 children in a study of EEE, Massachusetts and New Hampshire, 1970–2010*

Parameter comparisonCorrelation coefficient§
Inflammation vs. EEE virus0.82
Inflammation vs. lesion on MRI0.68
EEE virus vs. lesion on MRI0.52

*Lesions were observed by use of MRI (magnetic resonance imaging). EEE, eastern equine encephalitis; –, absent or none found.
†The degree of cerebral inflammation and amount of EEE virus antigen were scored 0–3 on the basis of histopathologic and immunohistopathologic findings.
‡Lesions seen on MRIs were scored 0–3 on the basis of the degree of T2 fluid-attenuated inversion recovery enhancement.
§Determined by using the Pearson correlation.

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