Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia
Figure 2. . . Mycobacterial interspersed repetitive unit–variable number tandem repeat (MIRU-VNTR) networks of major spoligotype clusters, Ethiopia, 2006–2010. Two large spoligotype clusters from lineage 4 (A) (90 isolates of sopligotype 149) and lineage 3 (B) (73 isolates of spoligotype 25) were further characterized by 24-loci MIRU-VNTR typing (Technical Appendix Table 2). Minimum-spanning trees were calculated for each cluster by using MIRU-VNTRplus (www.miru-vntrplus.org). Each circle indicates an individual genotype. Genotypes L and E1 include >15 isolates and remaining genotypes include <15 isolates. Genotypes indicated by a black circle were isolated from patients with pulmonary tuberculosis (TB); those in light gray were isolated from patients with TB lymphadenitis in cervical lymph nodes (TBLN); and those in dashed circles were isolated from patients with pulmonary TB and those with TBLN. Numbers on lines between circles indicate distance between 2 genotypes.