Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 19, Number 3—March 2013

Dispatch

Virulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France

Hélène Bodilis1 and Nicole GuisoComments to Author 
Author affiliations: Institut Pasteur, Paris, France; Centre National de la Recherche Scientifique (CNRS)

Main Article

Table 1

Characteristics and clinical signs and symptoms of patients <6 mo of age infected with Bordetella pertussis isolates negative or positive for pertactin, France, 2004–2011*

Variable Pertactin-negative isolate, n = 20 Pertactin-positive isolate, n = 40 p value
Male sex, % 60 50 0.46†
Age, d (range)
66 (16–147)
61 (23–132)
NA
Year of illness, % NA
2004 5 2.5 NA
2005 10 7.5 NA
2006 5 5 NA
2007 15 15 NA
2008 5 7.5 NA
2009 25 35 NA
2010 5 22.5 NA
2011
30
5
NA
Previous vaccination
4/19 (21.05)
8/39 (20.51)
0.96†
Vaccinated according to recommendations n = 19 n = 39 NA
Yes 2 (10.53) 4 (10.26) 1.0‡
No 5 (26.32) 10 (26.54) NA
Not eligible (<2 mo of age)
12 (63.16
25 (64.10)
NA
Time from onset of signs and symptoms to sample collection, d (range)
14.6 (1–37), n = 13
9.9 (2–35), n = 33
0.04§
Signs and symptoms
Nocturnal cough 6/7 (86) 19/22 (86) 1‡
Paroxysmal cough 16/16 (100) 35/36 (97) 1‡
Syncope 4/9 (44) 8/25 (32) 0.69‡
Vomiting 3/11 (27) 15/29 (52) 0.29‡
Loss of weight 5/10 (50) 10/25 (40) 0.71‡
Whoop 5/8 (62) 6/14 (43) 0.66‡
Apnea 5/8 (62) 11/24 (46) 0.68‡
Fever 2/11 (18) 3/31 (10) 0.59‡
Bradycardia 4/7 (57) 14/20 (70) 0.6‡
Atypical cough 1/9 (11) 6/17 (35) 0.36‡
Cyanosis/desaturation 9/11 (82) 20/25 (80) 1‡
Deterioration of general condition 4/9 (44) 9/28 (32) 0.77‡
Malignant pertussis 0/9 1/28 (4) NA
Hyperlymphocytosis
8/9 (89)
17/23 (74)
0.64‡
Hospitalization 16/18 (89) 36/39 (92) 0.65‡
Duration of hospitalization, d (range)
12.6 (1–45), n = 9
16.6 (1–60), n = 28
0.18§
Intensive care 5/10 (50) 13/30 (43) 0.73‡
Duration of intensive care, d (range) 8.2 (2–21), n = 5 5.4 (1–14), n = 12 0.24§

*Values are (no. patients with variable/no. of patients with data) except as indicated. NA, not applicable.
†χ2 test.
‡Fisher exact test.
§Mann-Whitney U test.

Main Article

1Current affiliation: Cochin Hospital, Paris, France

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO