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Volume 19, Number 4—April 2013

Research

Description and Nomenclature of Neisseria meningitidis Capsule Locus

Odile B. Harrison, Heike Claus, Ying Jiang, Julia S. Bennett, Holly B. Bratcher, Keith A. Jolley, Craig Corton, Rory Care, Jan T. Poolman, Wendell D. Zollinger, Carl E. Frasch, David S. Stephens, Ian Feavers, Matthias Frosch, Julian Parkhill, Ulrich Vogel, Michael A. Quail, Stephen D. Bentley, and Martin C.J. Maiden
Author affiliations: University of Oxford, Oxford, UK (O.B. Harrison, J.S. Bennett, H.B. Bratcher, K.A. Jolley, M.C.J. Maiden); University of Würzburg, Würzburg, Germany (H. Claus, M. Frosch, U. Vogel); The Sanger Institute, Cambridge, UK (Y. Jiang, C. Corton, J. Parkhill, M.A. Quail, S.D. Bentley); National Institute for Biological Standards and Control, Potters Bar, UK (R. Care, I. Feavers); Crucell, Leiden, the Netherlands (J.T. Poolman); Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (W.D. Zollinger); Frasch Biologics Consulting, Martinsburg, West Virginia, USA (C.E. Frasch); Emory University, Atlanta, Georgia, USA (D.S. Stephens)

Main Article

Table 2

Genetic diversity of Neisseria meningitidis cps genes*

Region, locus Size, bp No. alleles No. polymorphisms (%) p-distance dN/dS ratio G+C content
MLST
abcZ 433 11 52 (11) 0.046 0.04 51
adk 465 7 18 (4) 0.015 0.02 52
aroE 490 11 131 (7) 0.102 0.28 56
fumC 465 12 27 (6) 0.02 0.02 57
gdh 501 8 18 (4) 0.014 0.05 52
pdhC 480 13 61 (13) 0.041 0.08 56
pgm
450
10
62 (14)
0.055
0.11
54
Region B
ctrE 2,115 13 386 (18) 0.061 0.2 51
ctrF
1,260
12
59 (5)
0.012
0.14
49
Region C
ctrA 1,179 11 175 (15) 0.032 0.18 47
ctrB 1,164 8 264 (23) 0.051 0.10 46
ctrC 726 8 177 (24) 0.06 0.12 43
ctrD
651
7
87 (13)
0.057
0.1
46
Region D
rfbA 867 13 75 (9) 0.034 0.26 53
rfbB 1,083 15 312 (28) 0.067 0.12 53
rfbC 558 14 124 (220 0.09 0.22 55
galE
1,020
15
382 (37)
0.119
0.12
50
Region E
tex 2,274 13 173 (8) 0.019 0.09 59
NMC0060 1,007 8 24 (2.4) 0.003 0.91 40
NMC0061 345 5 24 (7) 0.013 0.19 36

*Genes in region A were too diverse among serogroups for direct comparison. Region D′ was omitted because galE2 is truncated and rfbA, rfbB, and rfbC were duplicates. MLST, multilocus sequence type.

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