Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
Figure 1. . Schematic diagram of the mature nonglycosylated prion protein and below amino acid sequences of the human and the simian prion polypeptide chain. Homology (198/207 aa) between human and simian mature cellular form of prion protein on the amino acid level is 96%. Large and small arrows indicate major and minor, respectively, proteinase K digestion sites (14). Open arrows indicate digestion sites in type 1 fragments; filled arrows indicate digestion sites in type 2 fragments. The epitopes recognized by the used monoclonal antibodies are shown below. OR, octarepeat region; H, α-helical structure; PK, proteinase K; M. fascicularis, Macaca fascicularis. *Swiss-Prot (www.ebi.ac.uk/swissprot/) accession numbers.