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Volume 19, Number 5—May 2013

Research

Changes in Severity of Influenza A(H1N1)pdm09 Infection from Pandemic to First Postpandemic Season, Germany

Nicola Lehners1, Steffen Geis1, Christoph Eisenbach, Kai Neben, and Paul SchnitzlerComments to Author 
Author affiliations: Author affiliation: University of Heidelberg, Heidelberg, Germany

Main Article

Table 2

Demographic and clinical characteristics of influenza- infected patients stratified by severity, University Hospital Heidelberg, 2009–10 and 2010–11, Germany*

Characteristic No. (%) patients
p value
Nonsevere diseases Severe disease
Total no. admitted patients 128 50
Male sex 61 (48) 31 (62) 0.08
Age, y, mean 18.4 47.9 <0.05
Days in hospital 6.4 20.2 <0.05
Pregnant 8 (6) 1 (2) 0.45
Pneumonia 22 (17) 40 (80) <0.05
Underlying medical condition 64 (50) 45 (90) <0.05
Immunosuppression 35 (27) 28 (56) <0.05
Cancer 1 (1) 5 (10) <0.05
Blood malignancy 12 (9) 13 (26) <0.05
Solid organ transplant 16 (13) 5 (10) 0.64
Autoimmune 6 (5) 5 (10) 0.19
Other 2 (2) 3 (6) 0.11
Chronic lung disease 11 (9) 11 (22) <0.05
Cardio vascular disease 29 (23) 29 (58) <0.05
Renal impairment 14 (11) 15 (30) <0.05
Diabetes 5 (4) 12 (24) <0.05
Metabolic dysfunction 16 (13) 12 (24) 0.06
Neurologic impairment 16 (13) 7 (14) 0.79
CRP level on admission, mg/L† 34.6 (range 1.99–213.6) 86.7 (range 1.99–381.4) <0.05
Leukocyte count on admission, /nL† 9.4 (range 1.9–108.7) 10.1 (range 0.1–48.8) 0.71

*CRP, C-reactive protein.
†Or the following day if not tested on admission.

Main Article

1These authors contributed equally to this article.

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