Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus
Figure 4. . . . tMRCA analysis across a range of fixed evolutionary rates. The tMRCA of EMC/2012 and England/Qatar/2012 estimated from fixing a range of genomic evolutionary rates (1 × 10−4, 2 × 10−4, 5 × 10−4, 1 × 10−3, 2 × 10−3, and 5 × 10−3 substitutions/site/year) are shown in data points with vertical error bars (95% highest posterior density). Evolutionary rate estimates of human CoV genome and genes in the literature are indicated at the bottom of the plot (mean or point estimate as a dot, 95% CIs of estimate as a square bracket). tMRCA, time to the most recent common ancestor; CoV, coronavirus; SARS, severe acute respiratory syndrome; ORF, open reading frame.