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Volume 19, Number 6—June 2013

Synopsis

New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States

J. Kamile RasheedComments to Author , Brandon Kitchel, Wenming Zhu, Karen F. Anderson, Nancye C. Clark, Mary Jane Ferraro, Patrice Savard, Romney M. Humphries, Alexander J. Kallen, and Brandi M. Limbago
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.K. Rasheed, B. Kitchel, W. Zhu, K.F. Anderson, N.C. Clark, A.J. Kallen, B.M. Limbago); Massachusetts General Hospital, Boston, Massachusetts, USA (M.J. Ferraro); Johns Hopkins University, Baltimore, Maryland, USA (P. Savard); Johns Hopkins Health System, Baltimore (P. Savard); University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA (R.M. Humphries)

Main Article

Table 4

Antimicrobial drug resistance determinants detected in clinical isolates and transformants, and incompatibility group assignment of blaNDM–bearing plasmids, United States, April 2009–March 2011*

Determinant Kp 0S-506 Kp 1100770 Kp 1100975 Kp 1100192 Kp 1000527 Kp 1101459 Sal 1101168 E. coli 1100101 E. coli 1001728 E. clo 1000654 E. coli recip.
β-lactam resistance†
I
TF
I
TF
I
TF
I
TF
I
TF
I
TF
I
TF
I
TF
I
TF
I
TF

blaCTX-M-1-Type + + + + + + + + + +
blaCMY-II-Type + + + + + + + + + + + + +
blaNDM
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

Aminoglycoside resistance‡
armA + + + + + + ND ND + + + +
rmtC






ND
ND
+
+






+
+



Plasmid replicon‡ A/C A/C A/C UT A/C UT L/M FII A/C FII

*Kp, Klebsiella pneumoniae; Sal, Salmonella enterica serovar Senftenberg; E. coli, Escherichia coli; E. Clo, Enterobacter cloacae; recip, recipient; I, isolate; TF, E. coli DH-10BT1 transformant containing a single New Delhi metallo-β-lactamase–encoding plasmid; +, target detected by the assay; –, target not detected by the assay; ND, not done (aminoglycoside resistance was not transferred); UT, untypeable by PCR replicon typing (22).
†Detected by using the Check-MDR CT101 microarray assay (23).
‡Detected by PCR.

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