Asynchronous Onset of Clinical Disease in BSE-Infected Macaques
Figure 1. . . Survival of intracerebrally BSE-infected cynomolgus macaques. Six age- and sex-matched cynomolgus macaques were inoculated intracerebrally with 50 mg brain homogenate (10% in sucrose) derived from 11 BSE-infected cattle. Macaques were euthanized at severe signs of neurodegenerative disease. The animals were grouped according to early (<1,200 dpi, n = 4) or late (>1,200 dpi, n = 2) onset of disease. The respective survival curves were compared by using a log-rank test (Mantel-Cox, p<0.05). BSE, bovine spongiform encephalopathy; dpi, days postinfection.