TY - JOUR AU - Montag, Judith AU - Schulz-Schaeffer, Walter AU - Schrod, Annette AU - Hunsmann, Gerhard AU - Motzkus, Dirk T1 - Asynchronous Onset of Clinical Disease in BSE-Infected Macaques T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 7 SP - 1125 SN - 1080-6059 AB - To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected. KW - Prion disease transmission KW - bovine spongiform encephalopathy KW - BSE KW - Macaca fascicularis KW - prion KW - prions KW - Creutzfeldt-Jakob disease DO - 10.3201/eid1907.120438 UR - https://wwwnc.cdc.gov/eid/article/19/7/12-0438_article ER - End of Reference