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Volume 19, Number 7—July 2013

Research

Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus

Beth N. Licitra1, Jean K. Millet1, Andrew D. Regan, Brian S. Hamilton, Vera D. Rinaldi, Gerald E. Duhamel, and Gary R. WhittakerComments to Author 
Author affiliations: Cornell University College of Veterinary Medicine, Ithaca, New York, USA

Main Article

Table 2

Sequence of FCoV spike at S1/S2 junction in cats sampled for feline coronavirus*

Time Cat 234 Cat 304
t = 1 NHTHTRRSRR↓SAPVAV NHTHTRRSRR↓SAPVAV
t = 2 NHTHTRRSLR↓SAPVAV NHTHTRRARR↓SAPVAV

*Underlines indicate nucleotide substitution. FCoV, feline coronavirus; S1/S2, cleavage site of spike protein; t = 1, both cats disease-free; ↓ , cleavage site; t = 2, cat 234 feline infectious peritonitis–positive, cat 304 disease-free.

Main Article

1These authors contributed equally to this article.

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