Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
Figure 1. . Mycobacterium tuberculosis co-culture competition experiment in a study of the amplification of multidrug resistance induced by first-line treatment of a mixed M. tuberculosis infection. The results suggest competitive advantages in vitro, which may account for patient strain phenotype in vivo. S, drug sensitive; R, drug resistant; OADC, oleic acid, albumin, dextrose, catalase growth supplement; OD600, optical density read at 600 nm; −INH, without isoniazid; +INH, with INH; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; CFU, colony-forming units.