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Volume 19, Number 9—September 2013
Research

Use of Staged Molecular Analysis to Determine Causes of Unexplained Central Nervous System Infections

Chien-Chin HsuComments to Author , Rafal Tokarz, Thomas Briese, Hung-Chin Tsai, Phenix-Lan Quan, and W. Ian Lipkin
Author affiliations: Columbia University, New York, New York, USA (C.-C. Hsu, R. Tokarz, T. Briese, P.-L. Quan, W.I. Lipkin); Southern Taiwan University of Science and Technology, Tainan, Taiwan (C.-C. Hsu); Chi-Mei Medical Center, Tainan (C.-C. Hsu); National Yang-Ming University Kaohsiung, Taiwan (H.-C. Tsai); Kaohsiung Veterans General Hospital, Kaohsiung (H.-C. Tsai)

Main Article

Table 4

EBV antibody in CSF and serum of patients identified with EBV infections by MassTag PCR*

Case CSF
Serum
VCA IgM VCA IgG EBV EA EBV NA VCA IgM VCA IgG EBV EA EBV NA
1 + +
2 + +
3 ND ND ND ND
4 + ND ND ND ND
5 + + + ND ND ND ND
6 + + +
7 + + +
8 + ND ND ND ND
9 + ND ND ND ND
10 + + +
11 + +
12 + + +
13 + ND ND ND ND
14 + ND ND ND ND
15 + ND ND ND ND
16 + +

*EBV antibody was measured by using commercial kit Euroimmun (Medizinische Labordiagnostika, Lübeck, Germany). Results were evaluated semiquantitatively by calculating a ratio of the extinction value of the control or patient samples over the extinction value of calibrator. Ratio <0.8: negative; ratio >1.1: positive. EBV, Epstein-Barr virus; CSF, cerebrospinal fluid; VCA, viral capsid antigen; EBV NA, EBV nuclear antigen indicating past EBV infections; EBV EA, EBV early antigen, indicating current or recent EBV infection; –, negative; +, positive; ND, not done.

Main Article

Page created: August 20, 2013
Page updated: August 20, 2013
Page reviewed: August 20, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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