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Volume 19, Number 9—September 2013

Research

Divergent Astrovirus Associated with Neurologic Disease in Cattle

Linlin Li, Santiago Diab, Sabrina McGraw, Bradd Barr, Ryan Traslavina, Robert Higgins, Tom Talbot, Pat Blanchard, Guillermo Rimoldi, Elizabeth Fahsbender, Brady Page, Tung Gia Phan, Chunlin Wang, Xutao Deng, Patricia PesaventoComments to Author , and Eric Delwart
Author affiliations: Blood Systems Research Institute, San Francisco, California, USA (L. Li, B. Page, T.G. Phan, X. Deng, E. Delwart); University of California San Francisco, San Francisco (L. Li, T.G. Phan, X. Deng, E. Delwart); University of California Davis, Davis, California, USA (S. Diab, S. McGraw, B. Barr, R. Traslavina, R. Higgins, P. Blanchard, G. Rimoldi, P. Pesavento); California Animal Health and Food Safety Laboratory, Davis (S. Diab, B. Barr, P. Blanchard, G. Rimoldi); Bishop Veterinary Hospital Inc., Bishop, California, USA (T. Talbot); University of South Florida, St. Petersburg, Florida, USA (E. Fahsbender); Stanford Genome Technology Center, Stanford, California, USA (C. Wang)

Main Article

Figure 1

Phylogenetic tree based on aligned amino acid sequences of the full length of the protease (open reading frame [ORF] 1a) (A), RNA-dependent RNA polymerase (ORF1b) (B), and capsid (ORF2) region (C) of representative astrovirus (AstV) species. BoAstV-NeuroS1 labeled with filled circle. AstVs with neurotropic potential labeled by empty circles. Clade containing these 3 viruses is shaded. Scale bar indicatesestimated protein sequence phylogenetic distance. GenBank accession numbers for astrovirus us

Figure 1. . Phylogenetic tree based on aligned amino acid sequences of the full length of the protease (open reading frame [ORF] 1a) (A), RNA-dependent RNA polymerase (ORF1b) (B), and capsid (ORF2) region (C) of representative astrovirus (AstV) species. BoAstV-NeuroS1 labeled with filled circle. AstVs with neurotropic potential labeled by empty circles. Clade containing these 3 viruses is shaded. Scale bar indicatesestimated protein sequence phylogenetic distance. GenBank accession numbers for astrovirus used in the analysis are as follows: bovine BoAstV-NeuroS1 (KF233994), human AstV-1 (JN887820), human AstV-4 (DQ344027), human AstV-6 (HM237363), human AstV MLB1 (JQ086552), human AstV MLB2 (NC_016155), human AstV-VA1 (FJ973620), human AstV-VA4 (JX857869), human AstV-HMO-A (NC_013443), human AstV-HMO-B (GQ415661), human AstV-HMO-C (GQ415662), human AstV-PS (GQ891990), ovine AstV (NC_002469), ovine AstV-2 (JN592482), bovine AstV B18 (HQ916313), bovine AstV-B34 (HQ916315), bovine AstV-B76 (HQ916316), bovine AstV-B170 (HQ916314), porcine AstV-2 (JF713712), porcine AstV-5 (JF713711), mink AstV (AY179509), mink AstV-SMS (GU985458), rabbit AstV (JF729316), and chicken AstV (JF414802).

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