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Volume 19, Number 9—September 2013


Divergent Astrovirus Associated with Neurologic Disease in Cattle

Linlin Li, Santiago Diab, Sabrina McGraw, Bradd Barr, Ryan Traslavina, Robert Higgins, Tom Talbot, Pat Blanchard, Guillermo Rimoldi, Elizabeth Fahsbender, Brady Page, Tung Gia Phan, Chunlin Wang, Xutao Deng, Patricia PesaventoComments to Author , and Eric Delwart
Author affiliations: Blood Systems Research Institute, San Francisco, California, USA (L. Li, B. Page, T.G. Phan, X. Deng, E. Delwart); University of California San Francisco, San Francisco (L. Li, T.G. Phan, X. Deng, E. Delwart); University of California Davis, Davis, California, USA (S. Diab, S. McGraw, B. Barr, R. Traslavina, R. Higgins, P. Blanchard, G. Rimoldi, P. Pesavento); California Animal Health and Food Safety Laboratory, Davis (S. Diab, B. Barr, P. Blanchard, G. Rimoldi); Bishop Veterinary Hospital Inc., Bishop, California, USA (T. Talbot); University of South Florida, St. Petersburg, Florida, USA (E. Fahsbender); Stanford Genome Technology Center, Stanford, California, USA (C. Wang)

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Figure 5

Cerebellum of a yearling steer with encephalomyelitis (animal 1). Note the selective extensive acute necrosis and degeneration of Purkinje cells. Numerous necrotic dendritic spheroids in the molecular layer with a cellular proliferation of Bergmann glia and of microgliosis. Hematoxylin and eosin stain. Original magnification ×400.

Figure 5. . Dorsal root ganglion of a heifer with encephalomyelitis (animal 2). Multifocal marked interstitial lymphocyte, macrophage, and plasma cell infiltrates with multifocal neuronal degeneration and necrosis can be seen. Hematoxylin and eosin stain. Original magnification ×400.

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