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Volume 2, Number 2—April 1996


Improved Serodiagnostic Testing for Lyme Disease: Results of a Multicenter Serologic Evaluation

Robert B. Craven*, Thomas J. Quan*, Raymond E. Bailey*, Raymond Dattwyler†, Raymond W. Ryan‡, Leonard H. Sigal§, Allen C. Steere¶, Bradley Sullivan#, Barbara J.B. Johnson*, David T. Dennis*, and Duane J. Gubler*
Author affiliations: *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; †State University of New York at Stony Brook, Stony Brook, New York, USA; ‡University of Connecticut Health Center, Farmington, Connecticut, USA; §University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA; ¶Tufts/New England Medical Center, Boston, Massachusetts, USA; #Marshfield Clinic, Marshfield, Wisconsin, USA

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Table 1

Accuracy and precision of serologic tests for Lyme disease performed in 1992

Accuracy (%) Precision(%)
Investigator Sensitivity Specificity Case
patients Non-case-
patients WCS
CDC (WCS) 93 71 93 77 69
CDC (FLA) 92 82 92 79 62
1 73 99.5 89 99 98
2 76 99 82 99 97
3 79 98 91 97 94
4 49 91 79 94 93
5 40 72 63 74 77

ª Specimens from patients with suspected cases that had borderline (equivocal) seroreactivity in an enzyme-linked immunosorbent assay with whole-cell sonicate antigen (WCS).

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