A Mathematical Model and CD4+ Lymphocyte Dynamics in HIV Infection
Figure 6. Simulated CD4+ and CD8+ lymphocyte dynamics after permanent treatment with anti-CD8 antibodies started 2 years after the acquisition of the HIV infection. Cells mediating the protective anti-HIV immune reaction are also affected by this treatment (R = 0.007, C = 0.007). *CD4+ cell observed values are depicted as circles and those of CD8+ lymphocytes as squares. Both simulated and observed values are depicted as a percentage of normal CD4+ lymphocyte numbers (the normal value of CD8+ lymphocytes is thus 66.7%).