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Volume 20, Number 4—April 2014
Letter

Nosocomial Drug-Resistant Bacteremia in 2 Cohorts with Cryptococcal Meningitis, Africa

Radha RajasinghamComments to Author , Darlisha Williams, David B. Meya, Graeme Meintjes, David R. Boulware, and James Scriven
Author affiliations: University of Minnesota, Minneapolis, Minnesota, USA (R. Rajasingham, D. Williams, D.B. Meya, D.R. Boulware); Makerere University, Kampala, Uganda (D. Williams, D.B. Meya); University of Cape Town, Cape Town, South Africa (G. Meintjes, J. Scriven); Imperial College London, London, UK (G. Meintjes); Liverpool School of Tropical Medicine, Liverpool, UK (J. Scriven)

Main Article

Table

Characteristics of 28 patients with cryptococcal meningitis, Uganda and South Africa, November 2010–April 2013*

Patient Blood culture isolate Hospital 30-d outcome Ceftriaxone susceptibility† Fluoroquinolone susceptibility†
1 Staphylococcus aureus (MRSA) K Died R NT
2 S. aureus (MRSA) K Survived R NT
3 S.. aureus (MRSA) C Survived R S
4 S. aureus (MRSA) C Survived R R
5 S. aureus (MRSA) C Died R S
6 S. aureus (MSSA) K Survived S NT
7 S. aureus (MSSA) K Survived S NT
8‡ S. aureus (MRSA) C Survived R R
8 Enterobacter cloacae C Survived R S
9 Klebsiella pneumoniae K Survived R R
10 K. pneumoniae K Died R R
11 K. pneumoniae K Survived S S
12 K. pneumoniae K Died R S
13 K. pneumoniae K Died R R
14 K. pneumoniae K Died R R
15 K. pneumoniae K Survived R R
16 K. pneumoniae C Survived R NT
17 K. pneumoniae C Died R S
18 Pseudomonas putida K Died S S
19 Pseudomonas aeruginosa K Survived R R
20 Pseudomonas spp. K Died R NT
21 Salmonella spp. K Survived S S
22 Salmonella spp. K Died S S
23 Burkholderia cepacia K Survived R NT
24 B. cepacia K Survived S S
25 Citrobacter freundii K Died R S
26 Acinetobacter baumanii K Survived R S
27 Enterobacter spp. K Died R R
28‡ Enterobacter cloacae C Survived R S
28 Stenotrophomonas maltophilia C Survived R R

*Sixteen (57%) of 28 patients survived; 7 (23%) of 30 isolates were susceptible to ceftriaxone, and 13 (54%) of 24 isolates were susceptible to fluoroquinolone. MSRA, methicillin-resistant S aureus; K, Kampala, Uganda; R, resistant; NT, not tested; C, Cape Town, South Africa; S, sensitive; MSSA, methicillin-sensitive S. aureus.
†Drug sensitivity testing performed by using the Kirby-Bauer method in Cape Town, South Africa, and a Phoenix Automated Microbiology System (Becton, Dickinson, Franklin Lakes, NJ, USA) in Kampala, Uganda.
‡Two patients each had 2 episodes of bacteremia.

Main Article

Page created: March 18, 2014
Page updated: March 18, 2014
Page reviewed: March 18, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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