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Volume 20, Number 4—April 2014

Research

Novel Betacoronavirus in Dromedaries of the Middle East, 2013

Patrick C.Y. Woo1Comments to Author , Susanna K.P. Lau1, Ulrich Wernery, Emily Y.M. Wong, Alan K.L. Tsang, Bobby Johnson, Cyril C.Y. Yip, Candy C.Y. Lau, Saritha Sivakumar, Jian-Piao Cai, Rachel Y.Y. Fan, Kwok-Hung Chan, Ringu Mareena, and Kwok-Yung Yuen
Author affiliations: The University of Hong Kong, Hong Kong, China (P.C.Y. Woo, S.K.P. Lau, E.Y.M. Wong, A.K.L. Tsang, C.C.Y. Yip, C.C.Y. Lau, J.-P. Cai, R.Y.Y. Fan, K.H. Chan, K.-Y. Yuen); Central Veterinary Research Laboratory, Dubai, United Arab Emirates (U. Wernery, B. Johnson, S. Sivakumar, R. Mareena)

Main Article

Table 2

Comparison of representative coronaviruses with a novel betacoronavirus, DcCoV UAE-HKU23, discovered in dromedaries in the Middle East, 2013*

Coronavirus (genome) Genome features
% Pairwise amino acid identity with DcCoV UAE-HKU23 (265F)
Size, bases G+C content
3CLpro RdRp Helicase S protein N protein
Alphacoronavirus
HCoV-229E 27,317 0.38 44.4 55.8 57.9 26.9 25.1
HCoV-NL63
27,553
0.34

42.8
56.0
57.5
26.4
24.1
Betacoronavirus
Lineage A
BCoV 31,028 0.37 99.7 99.9 99.5 94.1 98.4
SACoV 30,995 0.37 99.7 99.8 99.3 94.1 98.9
DcCoV UAE-HKU23 (362F) 31,036 0.37 99.7 100 100 99.8 100
DcCoV UAE-HKU23 (368F) 31,036 0.37 99.7 100 100 99.8 100
Lineage B
SARS-CoV 29,751 0.41 48.4 66.3 68.0 30.4 34.4
Lineage C
MERS-CoV 30,119 0.41 53.3 68.2 67.9 31.8 34.7
Lineage D
Ro-BatCoV HKU9
29,114
0.41

48.4
66.5
67.5
29.2
32.5
Gammacoronavirus
Infectious bronchitis virus 27,608 0.38 42.1 60.6 60.2 24.8 28.0
BdCoV HKU22
31,750
0.39

45.3
60.0
58.2
25.7
28.9
Deltacoronavirus
BuCoV HKU11 26,476 0.39 38.5 51.2 47.5 26.4 23.8
PorCoV HKU15 25,421 0.43 38.8 51.8 48.6 26.0 23.1

*The representative coronaviruses were those with complete genomes sequences available. DcCoV, dromedary camel coronavirus; 3CLpro, chymotrypsin-like protease; RdRp, RNA-dependent RNA polymerase; S protein, spike protein; N protein, nucleocapsid protein; HCoV, human CoV; BCoV, bovine CoV; SACoV, sable antelope CoV; SARS-CoV, severe acute respiratory syndrome CoV; MERS-CoV, Middle East respiratory syndrome CoV; Ro-BatCoV, rousettus bat CoV; BdCoV, bottlenose dolphin CoV; BuCoV, bulbul CoV; PorCoV, porcine CoV.

Main Article

1These authors contributed equally to this article.

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