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Volume 20, Number 4—April 2014

Etymologia

Etymologia: Pertactin

Suggested citation for this article

Pertactin [per-takʹtin]

From per- (pertussis) + tactus (Latin, “to touch”), pertactin is a virulence factor of Bordetella pertussis that promotes adhesion to tracheal epithelial cells and resistance to neutrophil-mediated clearance and is a component of acellular pertussis vaccines. Pertactin-negative B. pertussis has been reported in several countries, and its prevalence in the United States has increased in recent years. However, evidence suggests that other components of current pertussis vaccines provide protection against pertactin-negative strains.

References

  1. Inatsuka CS, Xu Q, Vujkovic-Cvijin I, Wong S, Stibitz S, Miller JF, Pertactin is required for Bordetella species to resist neutrophil-mediated clearance. Infect Immun. 2010;78:29019 . DOIPubMed
  2. Leininger E, Roberts M, Kenimer JG, Charles IG, Fairweather N, Novotny P, Pertactin, an Arg-Gly-Asp–containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc Natl Acad Sci U S A. 1991;88:3459. DOIPubMed
  3. Pawloski LC, Queenan AM, Cassiday PK. Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States. Proc Natl Acad Sci USA. 1991;88:345–9. Clin Vaccine Immunol. 2014;21:11925. DOIPubMed

Suggested citation for this article: Etymologia: Pertactin. Emerg Infect Dis [Internet]. 2014 Apr [date cited]. http://dx.doi.org/10.3201/eid2004.ET2004

DOI: 10.3201/eid2004.ET2004

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Table of Contents – Volume 20, Number 4—April 2014

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