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Volume 20, Number 5—May 2014

Research

Treatment Practices, Outcomes, and Costs of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, United States, 2005–2007

Suzanne M. MarksComments to Author , Jennifer Flood, Barbara Seaworth, Yael Hirsch-Moverman, Lori Armstrong, Sundari Mase, Katya Salcedo, Peter Oh, Edward A. Graviss, Paul W. Colson, Lisa Armitige, Manuel Revuelta, Kathryn Sheeran, and the TB Epidemiologic Studies Consortium
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.M. Marks, L. Armstrong, S. Mase, TB Epidemiologic Studies Consortium); California Department of Public Health, Richmond, California, USA (J. Flood, K. Salcedo, P. Oh); Texas Department of State Health Services, Tyler, Texas, USA (B. Seaworth, L. Armitige, K. Sheeran); University of Texas Health Science Center, Tyler (B. Seaworth, L. Armitige, K. Sheeran); ICAP/Columbia University, New York, New York, USA (Y. Hirsch-Moverman, P.W. Colson, M. Revuelta); Methodist Hospital Research Institute, Houston, Texas, USA (E.A. Graviss)

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Table 3

Clinical characteristics of study participants and other patients with MDR and/or XDR TB, United States, 2005–2007*

Characteristic Study participants, no. (%), n = 135 All US MDR TB patients, no. (%), n = 370
History of LTBI, % of 130 known 21 (16)
History of completing LTBI Rx, % of 21 with history of LTBI 14 (67)
History of TB disease† 48 (36) 60 (16)
Contact with infectious TB patient, % of 87 known 10 (11)
Contact with infectious MDR TB patient, % of 10 contacts 6 (60)
Dead at TB diagnosis 1 (1) 5 (1)
Smear positive at any time, % of 134 alive at diagnosis†
103 (77)
223 (60)
Sites of TB disease
Pulmonary 115 (85) 332 (90)
Extrapulmonary only 8 (6) 37 (10)
Disseminated at any time
12 (9)

Extent of pulmonary disease at diagnosis
Extensive 69
Moderate 31
Minimal 21
Undocumented
6

Description of extensive pulmonary disease, at any time
Miliary 4
Cavitary 58 127
Multiple lobes 70
Collapsed lobes
6

Extent of extrapulmonary disease at diagnosis
Extensive 2
Moderate 3
Minimal
3

*MDR, multidrug resistant; XDR, extensively drug resistant; TB, tuberculosis; LTBI, latent TB infection; Rx, treatment. Blank cells indicate data not available.
†Statistically significant differences between percentages of study patients and all US MDR TB patients at p<0.05.

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