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Volume 20, Number 5—May 2014

Research

Treatment Practices, Outcomes, and Costs of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, United States, 2005–2007

Suzanne M. MarksComments to Author , Jennifer Flood, Barbara Seaworth, Yael Hirsch-Moverman, Lori Armstrong, Sundari Mase, Katya Salcedo, Peter Oh, Edward A. Graviss, Paul W. Colson, Lisa Armitige, Manuel Revuelta, Kathryn Sheeran, and the TB Epidemiologic Studies Consortium
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.M. Marks, L. Armstrong, S. Mase, TB Epidemiologic Studies Consortium); California Department of Public Health, Richmond, California, USA (J. Flood, K. Salcedo, P. Oh); Texas Department of State Health Services, Tyler, Texas, USA (B. Seaworth, L. Armitige, K. Sheeran); University of Texas Health Science Center, Tyler (B. Seaworth, L. Armitige, K. Sheeran); ICAP/Columbia University, New York, New York, USA (Y. Hirsch-Moverman, P.W. Colson, M. Revuelta); Methodist Hospital Research Institute, Houston, Texas, USA (E.A. Graviss)

Main Article

Table 4

Characteristics associated with any acquired antimicrobial drug resistance during MDR TB Treatment, 128 patients, California, Texas, and New York City, USA, 2005–2007*†

Variable Initial OR estimate Initial 95% CI Initial Pr>χ2 Final OR estimate Final 95% CI Final Pr>χ2
Age >65 y <0.001 <0.001–>999.999 0.973
Black race 33.19 0.80–>999.999 0.065 4.07 1.08–15.37 0.039
Recent homelessness 18.76 0.93–377.71 0.056 5.81 1.17–28.86 0.031
Pre-XDR or XDR TB 8.78 2.31–33.42 0.001 5.15 1.86–14.21 0.002
AFB-smear positive 5.34 0.86–33.22 0.072
Age 25-44 y 4.83 0.65–36.03 0.124
Hispanic ethnicity 4.83 0.11–216.20 0.417
≥4 Effective medications 3.46 0.41–29.47 0.256
Age 45–64 y 3.41 0.39–30.21 0.271
Asian race 3.35 0.07–151.32 0.534
Disseminated TB disease 2.28 0.21–24.20 0.495
Foreign born 2.10 0.15–28.64 0.577
Recent cigarette smoker 1.96 0.41–9.31 0.397
Recent excess alcohol use 0.99 0.13–7.65 0.988
TB clinic outpatient management 0.98 0.18–5.35 0.980
Recent unemployment 0.97 0.24–3.93 0.964
Cavitary disease 0.77 0.21–2.84 0.694
Diabetes 0.76 0.16–3.70 0.732
History of TB disease 0.44 0.12–1.59 0.208
HIV infection 0.39 0.03–4.92 0.463
Recent injection drug or noninjection drug use 0.15 0.00–5.08 0.291

*MDR TB, multidrug-resistant tuberculosis; XDR TB, extensively drug-resistant TB; OR, odds ratio; AFB, acid-fast bacilli; Pr, probability. Boldface indicates significance in the final model. Blank cells indicate variables not retained in the final model.
†Model fit intercept and covariates: Akaike information criterion, initial 136.392, final 116.619; Schwarz criterion, initial 198.964, final 127.996; –2logL, initial 92.392, final 108.619.

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