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Volume 20, Number 5—May 2014

Research

Treatment Practices, Outcomes, and Costs of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, United States, 2005–2007

Suzanne M. MarksComments to Author , Jennifer Flood, Barbara Seaworth, Yael Hirsch-Moverman, Lori Armstrong, Sundari Mase, Katya Salcedo, Peter Oh, Edward A. Graviss, Paul W. Colson, Lisa Armitige, Manuel Revuelta, Kathryn Sheeran, and the TB Epidemiologic Studies Consortium
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.M. Marks, L. Armstrong, S. Mase, TB Epidemiologic Studies Consortium); California Department of Public Health, Richmond, California, USA (J. Flood, K. Salcedo, P. Oh); Texas Department of State Health Services, Tyler, Texas, USA (B. Seaworth, L. Armitige, K. Sheeran); University of Texas Health Science Center, Tyler (B. Seaworth, L. Armitige, K. Sheeran); ICAP/Columbia University, New York, New York, USA (Y. Hirsch-Moverman, P.W. Colson, M. Revuelta); Methodist Hospital Research Institute, Houston, Texas, USA (E.A. Graviss)

Main Article

Table 5

Characteristics associated with expert consultation for 134 patients during MDR TB treatment, California, Texas, and New York, NY, USA, 2005–2007*†

Variable Initial OR estimate Initial 95% CI Initial Pr>χ2 Final OR estimate Final 95% CI Final Pr>χ2
XDR TB >999.999 <0.001–>999.999 0.939
Recent homelessness >999.999 <0.001–>999.999 0.887
Correctional institution residence >999.999 <0.001–>999.999 0.939
Recent injection drug or noninjection drug use 61.63 0.00–>999.999 0.401
Recent cigarette smoker 27.88 0.56–>999.999 0.096
Diabetes 26.44 1.28–545.80 0.034
Disseminated TB disease 9.49 0.18–501.11 0.266
TB clinic outpatient management 7.96 1.50–42.32 0.015 5.67 1.93–16.64 0.002
Age 45–64 y 4.30 0.38–48.55 0.239
Recent unemployment 3.81 0.52–28.18 0.190
Age 25–44 years 2.92 0.58–14.63 0.192
Long-term care facility resident 1.87 <0.001–>999.999 0.878
5-drug regimen 1.13 0.22–5.82 0.882
Total no. adverse events 1.12 0.88–1.42 0.371
Total first-line resistance 0.63 0.11–3.77 0.614
Acquired resistance 0.57 0.07–4.37 0.588
Foreign born 0.55 0.03–12.28 0.705
History of TB disease 0.53 0.13–2.10 0.363
Age >65 y 0.50 0.02–14.97 0.687
HIV infection 0.34 0.02–7.21 0.492
Pregnant 0.28 0.02–5.15 0.393
Private insurance 0.14 0.02–0.87 0.035 0.23 0.08–0.68 0.008
Pre-XDR 0.12 0.01–1.35 0.087
Male 0.12 0.02–0.82 0.031
Died 0.05 <0.001–3.46 0.165
White race 0.05 <0.001–>999.999 0.988
Recent excess alcohol use <0.001 <0.001–0.06 0.002 0.19 0.05–0.72 0.014
Black race <0.001 <0.001–>999.999 0.937
Hispanic ethnicity <0.001 <0.001–>999.999 0.938
Asian race <0.001 <0.001–>999.999 0.943

*MDR TB, multidrug-resistant tuberculosis; XDR TB, extensively drug-resistant TB; OR, odds ratio. Boldface indicates significance in the final model. Blank cells indicate variables not retained in the final model.
†Model fit intercept and covariates: AIC (initial 133.402, final 121.683), SC (initial 223.235, final 133.274); –2logL (initial 71.402, final 113.683).

Main Article

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