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Volume 20, Number 5—May 2014

Research

Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States

Martin SteinauComments to Author , Mona Saraiya, Marc T. Goodman, Edward S. Peters, Meg Watson, Jennifer L. Cleveland, Charles F. Lynch, Edward J. Wilkinson, Brenda Y. Hernandez, Glen Copeland, Maria S. Saber, Claudia Hopenhayn, Youjie Huang, Wendy Cozen, Christopher Lyu, Elizabeth R. Unger, and the HPV Typing of Cancers Workgroup
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M. Steinau, M. Saraiya, M. Watson, J.L. Cleveland, E.R. Unger); Cedars-Sinai Medical Center, Los Angeles, California, USA (M.T. Goodman); Louisiana State University, New Orleans, Louisiana, USA (E.S. Peters); University of Iowa, Iowa City, Iowa, USA (C.F. Lynch); University of Florida, Gainesville, Florida, USA (E.J. Wilkinson); University of Hawaii, Honolulu, Hawaii, USA (B.Y. Hernandez); Michigan Cancer Surveillance Program, Lansing, Michigan, USA (G. Copeland); Los Angeles Cancer Registry, Los Angeles, California, USA (M.S. Saber, W. Cozen); University of Kentucky, Lexington, Kentucky, USA (C. Hopenhayn); Florida Department of Health, Tallahassee, Florida, USA (Y. Huang); Battelle Memorial Institute, Durham, North Carolina, USA (C. Lyu)

Main Article

Figure 1

Hierarchical designation of human papillomavirus (HPV) types to oropharyngeal squamous cell carcinomas. White sections of bars indicate attribution of the specific HPV type or group. Black sections of bars indicate cumulative prevalence of types in higher hierarchy. HPV-16 includes all cases positive for this type regardless of other results. HPV-18 includes all cases positive for HPV-18, but negative for HPV-16. Cases of 9-valent HPV with high-risk HPV types included in the candidate 9-valent H

Figure 1. Hierarchical designation of human papillomavirus (HPV) types to oropharyngeal squamous cell carcinomasWhite sections of bars indicate attribution of the specific HPV type or groupBlack sections of bars indicate cumulative prevalence of types in higher hierarchyHPV-16 includes all cases positive for this type regardless of other resultsHPV-18 includes all cases positive for HPV-18, but negative for HPV-16Cases of 9-valent HPV with high-risk HPV types included in the candidate 9-valent HPV vaccine: HPV-31, -33, -45, -52, -58, but not HPV-16 or -18High-risk: cases positive for any high-risk type not included in the previous categories: HPV-35, -39, -51, -66, -68Low-risk: cases only positive for HPV types with low or no oncogenic potential.

Main Article

1Members of HPV Typing of Cancers Workgroup who contributed to this study are listed at the end of this article.

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