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Volume 20, Number 5—May 2014

Research

Molecular Characterization of Cryptically Circulating Rabies Virus from Ferret Badgers, Taiwan

Hue-Ying Chiou, Chia-Hung Hsieh, Chian-Ren Jeng, Fang-Tse Chan, Hurng-Yi Wang, and Victor Fei PangComments to Author 
Author affiliations: National Taiwan University, Taipei, Taiwan, Republic of China (H.-Y. Chiou, C.-H. Hsieh, C.-R. Jeng, H.-Y. Wang, V.F. Pang); Council of Agriculture, Executive Yuan, Nantou County, Taiwan, Republic of China (F.-T. Chan)

Main Article

Figure 5

Maximum-likelihood trees of rabies virus based on (A) nucleoprotein and (B) glycoprotein gene sequences. Numbers on the branches are estimated divergences (above) and their 95% highest posterior density (below). The divergence time between different viral lineages and time to the most recent common ancestor of virus isolates were estimated by using an established Bayesian Markov chain Monte Carlo approach implemented in BEAST version 1.7 (21). The substitution rate was assumed to be 4.3 × 10–4 (

Figure 5. Maximum-likelihood trees of rabies virus based on (A) nucleoprotein and (B) glycoprotein gene sequencesNumbers on the branches are estimated divergences (above) and their 95% highest posterior density (below)The divergence time between different viral lineages and time to the most recent common ancestor of virus isolates were estimated by using an established Bayesian Markov chain Monte Carlo approach implemented in BEAST version 1.7 (21)The substitution rate was assumed to be 4.3 × 10–4 (range 3.1–6.6 × 10–4) or 2.3 × 10–4 (range 1.1–3.6 × 10–4)/sites/year (hatched numbers) for nucleoprotein (N) and 3.9 × 10–4 (1.2–6.5 × 10–4)/sites/year for glycoprotein (G) genes (17,23)The analysis was performed by using the general time-reversible model of nucleotide substitution, assuming an uncorrelated lognormal molecular clock (22)TW1955 is the only isolate from a shrew that is very close to TW1614 collected from the same area, suggesting that TW1955 was a spillover from a ferret badger (see also Figure 1)Scale bar indicates nucleotide substitutions per site.

Main Article

1Joint senior authors who contributed equally to this article.

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