Volume 20, Number 5—May 2014
Acute Lower Respiratory Tract Infections in Soldiers, South Korea, April 2011–March 2012
During April 2011–March 2012, we retrospectively reviewed medical records for South Korea soldiers to assess the etiology and epidemiology of acute viral lower respiratory tract infections. Adenovirus was the most commonly identified virus (63.2%) and the most common cause of pneumonia (79.3%) and hospitalization (76.6%); 3 soldiers died of adenovirus-related illness.
Respiratory infections are the most common cause for hospitalization of soldiers. In the US military, respiratory infections account for 25%–30% of all hospital admissions for infectious diseases (1). Adenovirus is the most common cause of acute respiratory infection in soldiers, particularly among new recruits in basic training camps (2,3). A study among US military showed that in the early phases of basic training, ≈10% of new recruits were infected with adenovirus, and among recruits with pneumonia, 90% of the cases were caused by adenovirus (4). In US military, adenovirus serotypes 4 and 7 have been historically the most common cause of febrile respiratory illness (5–8). Since 1971, the US military has orally vaccinated new recruits with live adenovirus vaccine; this vaccination has become the primary preventive strategy against respiratory diseases caused by adenovirus (9,10).
In spring 2006 in South Korea, a high adenovirus prevalence of 61% was found among military recruits with mild respiratory disease (11). More recently in South Korea, deaths caused by severe pneumonia were reported among the military, and an outbreak of acute respiratory disease caused by adenovirus occurred in an army training camp (12,13). We hypothesized that, although there may be some differences in etiologic agents by geographic location, the major cause of acute respiratory disease in South Korean military recruits is most likely adenovirus, as observed in the US military. To describe the viral etiology, clinical features, and epidemiologic characteristics of acute lower respiratory tract infections (LTRIs) among the South Korean military, we retrospectively reviewed the medical records of soldiers who were identified with an acute LTRI.
The study was conducted during April 2011–March 2012 at the Armed Forces Capital Hospital, a military referral hospital in Seongnam, South Korea. We retrospectively reviewed all medical records with International Classification of Diseases, Tenth Revision, Clinical Modification codes indicating acute LTRI (pneumonia, tracheobronchitis, or bronchiolitis); 622 patient records met the criteria and were reviewed. General characteristics of the study population and the military hospital, as well as the method used for classifying clinical diagnoses of acute LTRI, are available in the Technical Appendix [PDF - 64 KB - 4 pages].
Nasopharyngeal swab specimens were collected from 207 (33.3%) of the 622 patients with an acute LTRI. Within 3 days, the specimens were tested (GClabs, Yongin-si, South Korea) for 12 respiratory viruses by multiplex reverse transcription PCR; methods are described in the Technical Appendix [PDF - 64 KB - 4 pages]. Respiratory virus infections were confirmed for 87 (42.0%) patients: adenovirus (55 [63.2%] patients), influenza A virus (26 [29.9%] patients), influenza B virus (4 [4.6%] patients), rhinovirus group A (3 [3.4%] patients), and parainfluenza virus (2 [2.3%] patients). Co-infection with adenovirus and rhinovirus group A was observed in 3 patients. For all confirmed cases of viral infection, we performed an epidemiologic analysis and analyzed the clinical manifestations and prognosis for the hospitalized patients.
The clinical diagnoses for acute viral LTRI cases included 58 cases of pneumonia, 25 cases of tracheobronchitis, and 4 cases of bronchiolitis. Pneumonia was most commonly caused by adenovirus (46 [79.3%] cases) (Table 1). Tracheobronchitis was most commonly caused by influenza A virus and adenovirus (14 [56.0%] and 9 [36.0%] cases, respectively). Two cases each of influenza A virus infection and parainfluenza virus infection were noted among the 4 patients with bronchiolitis. The monthly distribution of the identified viruses is shown in the online Technical Appendix Figure.
Of the 87 patients with an LTRI, 64 were hospitalized. Among these 64 patients, 49 (76.6%) had adenovirus infections, 13 (20.3%) had influenza A or B virus infections, and 2 had bronchiolitis caused by parainfluenza virus infection. Table 2 shows the clinical features of the 62 patients hospitalized for adenovirus or influenza A or B virus infection, among whom the mean age was 19.6 ± 1.1 years (adenovirus patients) and 20.1 ± 2.0 years (influenza patients). Except for a female patient infected with influenza A virus, all patients were male. The proportion of new military recruits was significantly higher among patients with adenovirus infection than among patients with influenza A or B virus infection (p = 0.011). There was no difference in the clinical signs and symptoms and radiographic findings of patients infected with influenza virus and adenovirus (Technical Appendix [PDF - 64 KB - 4 pages]). Mechanical ventilation was required for 6 patients in whom severe pneumonia developed; all 6 patients had adenovirus infection and 3 died (Technical Appendix [PDF - 64 KB - 4 pages]).
Among the viruses identified as causing acute LTRI in South Korean soldiers, adenovirus was the most common, causing 63.2% of the cases. In addition, adenovirus was identified in 79.3% of pneumonia cases. These findings are similar to those in studies among US military (1–4).
Adenovirus infection was more common among new recruits in the South Korean military. However, the infection was also confirmed in all 11 (64.7%) privates among the 17 active duty soldiers at advanced training sites (Table 2). In the South Korea military, adenovirus might have spread to secondary training sites through recruit redeployment, similar to the experience in the US military (14).
Cases of severe pneumonia requiring mechanical ventilation were not observed among patients with influenza virus infection; however, 3 of the 6 patients with severe adenovirus-associated pneumonia died. This finding indicates that adenovirus infection is a major cause of death among soldiers with severe respiratory diseases. In 2009, in response to the influenza A(H1N1)pdm09 pandemic, multiplex reverse transcription PCR for respiratory viruses became available in South Korea military hospitals. Before 2009, apart from research purposes, clinical testing for respiratory viruses was not routinely performed at military hospitals. For this reason, South Korea military physicians were unaware that adenovirus was a major cause of respiratory disease among soldiers. Because of the lack of an effective treatment for adenovirus infection, vaccination against adenovirus has been introduced for persons, such as military recruits, at high risk for infection.
Our study has certain limitations. First, we were unable to confirm the serotype of adenovirus for positive case-patients. Because military physicians were unaware that adenovirus was a major cause of acute respiratory disease, additional serotyping was not performed at the time of diagnosis. Second, the period of study was only 1 year. The level of an epidemic varies at different times, thus requiring longer study periods to observe patterns. Third, we retrospectively reviewed medical records of patients with acute LTRI in a central referral military hospital; thus, the study patients may not be entirely representative of South Korea soldiers with acute LTRI. Last, there was a sampling bias with regard to the molecular assay; the test may have been performed only in cases of severe illness or when recommended by clinicians. Nevertheless, our results suggest that among South Korea soldiers with acute LTRIs, those with adenovirus rather than other respiratory infections had more severe clinical outcomes.
Further studies are required to determine the serotype(s) of adenovirus causing infection among the military, and epidemiologic surveillance for adenovirus is needed. In addition, studies on the effectiveness of adenovirus vaccine should be considered.
Dr Heo is a military physician in the Division of Infectious Diseases at the Armed Forces Capital Hospital. His current research interest is the epidemiology of vaccine-preventable and vector-borne diseases in military personnel in South Korea.
Dr Lee is a civilian physician in the Division of Pulmonary and Critical Care Medicine at the Armed Forces Capital Hospital. Her primary research interests are pulmonary diseases of both infectious (pneumonia and tuberculosis) and noninfectious (e.g., idiopathic acute eosinophilic pneumonia) origin that occur frequently in military personnel in South Korea.
We thank staff at GClabs, Yongin-si, South Korea, for technical assistance.
This study was supported by a fund from the Armed Forces Medical Command‚ South Korea.
- Pazzaglia G, Pasternack M. Recent trends of pneumonia morbidity in US Naval personnel. Mil Med. 1983;148:647–51 .
- Gray GC, Goswami PR, Malasig MD, Hawksworth AW, Trump DH, Ryan MA, Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics. Clin Infect Dis. 2000;31:663–70 .
- Russell KL, Hawksworth AW, Ryan MA, Strickler J, Irvine M, Hansen CJ, Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004. Vaccine. 2006;24:2835–42.
- Gray GC, Callahan JD, Hawksworth AW, Fisher CA, Gaydos JC. Respiratory diseases among US military personnel: countering emerging threats. Emerg Infect Dis. 1999;5:379–85.
- Erdman DD. XuW, GerberSI, GrayGC, SchnurrD, KajonAE, et al.Molecular epidemiology of adenovirus type 7 in the United States, 1966–2000.Emerg Infect Dis. 2002;8:269–77 and.
- Hilleman MR. Epidemiology of adenovirus respiratory infections in military recruit populations. Ann N Y Acad Sci. 1957;67:262–72 and.
- Barraza EM, Ludwig SL, Gaydos JC, Brundage JF. Reemergence of adenovirus type 4 acute respiratory disease in military trainees: report of an outbreak during a lapse in vaccination. J Infect Dis. 1999;179:1531–3.
- Blasiole DA, Metzgar D, Daum LT, Ryan MA. WuJ, WillsC, et al.Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults.J ClinMicrobiol.2004;42:1686–93 and.
- Gaydos CA, Gaydos JC. Adenovirus vaccines in the US military. Mil Med. 1995;160:300–4 .
- HokeCHJr. HawksworthA, SnyderCEJr. Initial assessment of impact of adenovirus type 4 and type 7 vaccine on febrile respiratory illness and virus transmission in military basic trainees, March 2012. MSMR.2012;19:2–4.
- Jeon K, Kang CI, Yoon CH, Lee DJ, Kim CH, Chung YS, High isolation rate of adenovirus serotype 7 from South Korean military recruits with mild acute respiratory disease. Eur J Clin Microbiol Infect Dis. 2007;26:481–3.
- Heo JY, Kim HK, Cha YJ, Lee JE, Shim YS, Choe KW. A clinical features of severe adenovirus pneumonia among members of the Korea military: a case series [in Korean]. Infection and Chemotherapy. 2012;44:372–6.
- Hwang SM, Park DE, Yang YI, Park SJ, Lee HK, Kim MJ, Outbreak of febrile respiratory illness caused by adenovirus at a South Korean military training facility: clinical and radiological characteristics of adenovirus pneumonia. Jpn J Infect Dis. 2013;66:359–65 .
- Trei JS, Johns NM, Garner JL, Noel LB, Ortman BV, Ensz KL, Spread of adenovirus to geographically dispersed military installations, May–October 2007. Emerg Infect Dis. 2010;16:769–75 .
Suggested citation for this article: Heo JY, Lee JE, Kim HK, Choe KW. Acute lower respiratory tract infections in soldiers, South Korea, April 2011–March 2012.Emerg Infect Dis. 2014 May [date cited]. http://dx.doi.org/10.3201/eid2005.131692
1These authors contributed equally to this article.
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