TY - JOUR AU - Falagas, Matthew AU - Tansarli, Giannoula AU - Karageorgopoulos, Drosos AU - Vardakas, Konstantinos T1 - Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 7 SP - 1170 SN - 1080-6059 AB - We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case–control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%–44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, −3% and −4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable. KW - carbapenem resistance KW - bloodstream infection KW - Enterobacteriaceae KW - carbapenem-resistant Enterobacteriaceae KW - infections KW - Klebsiella pneumoniae KW - Klebsiella pneumoniae carbapenemase KW - KPC KW - bacteremia KW - carbapenemases KW - carbapenemase-producing KW - attributable mortality KW - mortality KW - attributable deaths KW - deaths KW - systematic review KW - metaanalysis KW - meta-analysis KW - outcome KW - bacteria DO - 10.3201/eid2007.121004 UR - https://wwwnc.cdc.gov/eid/article/20/7/12-1004_article ER - End of Reference