TY - JOUR AU - Falzarano, Darryl AU - Safronetz, David AU - Prescott, Joseph AU - Marzi, Andrea AU - Feldmann, Friederike AU - Feldmann, Heinz T1 - Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 6 SP - 1065 SN - 1080-6059 AB - The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes. KW - Ebola virus infection KW - antiviral drug KW - animal model KW - chloroquine KW - treatment KW - viruses KW - antimicrobial drugs DO - 10.3201/eid2106.150176 UR - https://wwwnc.cdc.gov/eid/article/21/6/15-0176_article ER - End of Reference