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Volume 21, Number 9—September 2015
CME ACTIVITY - Synopsis

Mycobacterium abscessus Complex Infections in Humans

Meng-Rui Lee, Wang-Huei Sheng, Chien-Ching Hung, Chong-Jen Yu, Li-Na Lee, and Po-Ren HsuehComments to Author 
Author affiliations: National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan (M.-R. Lee, W.-H. Sheng, C.-C. Hung, C.-J. Yu, L.-N. Lee, P.-R. Hsueh); National Taiwan University Hospital, Taipei, Taiwan (M.-R. Lee, W.-H. Sheng, C.-C. Hung, C.-J. Yu, L.-N. Lee, P.-R. Hsueh)

Main Article

Table 1

Summary of recent data on the resistance of Mycobacterium abscessus complex bacteria to different antimicrobial agents*

Study authors (reference), species No. isolates Antimicrobial drug, no. resistant isolates/no. tested (%)
CLR DOX CIP MXF FOX AMK IPM
Lee et al. (34)
M. abscessus subsp. abscessus 202 48/202 (24) NA 184/202 (91) 167/202 (83) NA 25/202 (12) NA
M. abscessus subsp. massiliense
199
15/199 (8)
NA
174/199 (87)
149/199 (75)
NA
12/199 (6)
NA
Koh et al. (18)
M. abscessus subsp. abscessus 64 3/64 (5) 53/64 (83) 37/64 (58) 30/64 (47) 0/64 3/64 (5) 27/62 (44)
M. abscessus subsp. massiliense
79
3/79 (4)
58/79 (73)
48/79 (61)
42/79 (53)
1/79 (1)
6/79 (8)
50/75 (67)
Huang et al. (35)
M. abscessus complex
40
3/40 (8)
37/40 (93)
36/40 (90)
31/40 (78)
27/40 (68)
2/40 (5)
35/40 (88)
Brown-Elliott et al. (36)
M. abscessus complex
37
0% (0/37)
NA
29/37 (78)
29/37 (78)
NA
0/37
7/37 (19)
Broda et al. (37)
M. abscessus complex
58
22/58 (38)
57/58 (98)
55/58 (95)
55/58 (95)
16/58 (28)
10/58 (17)
56/58 (97)
Zhuo et al. (38)
M. abscessus complex
70
10/70 (14)
NA
56/70 (80)
NA
3/70 (4)
0/70
15/70 (21)
Overall
M. abscessus complex 749 104/749 (13.9) 205/241 (85.1) 619/749 (82.6) 503/679 (74.1) 47/311 (15.1) 58/749 (7.7) 190/342 (55.6)
M. abscessus subsp. abscessus 266 51/266 (19.4) 53/64 (83.0) 221/266 (83.1) 197/266 (74.1) 0/64 28/266 (10.5) 27/62 (44.0)
M. abscessus subsp. massiliense 278 18/278 (6.5) 58/79 (73.4) 222/278 (79.8) 191/278 (68.7) 1/79 (1.0) 18/278 (6.5) 50/75 (66.7)

*AMK, amikacin; CIP, ciprofloxacin; CLR, clarithromycin; DOX, doxycycline; FOX, cefoxitin; IPM, imipenem; MXF, moxifloxacin; NA, not available.

Main Article

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