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Volume 22, Number 10—October 2016
Research

Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples

Goutam Chowdhury, Gururaja Perumal Pazhani, Anirban Sarkar, Krishnan Rajendran, Asish K. Mukhopadhyay, Mihir K. Bhattacharya, Amit Ghosh, and Thandavarayan RamamurthyComments to Author 
Author affiliations: National Institute of Cholera and Enteric Diseases, Kolkata, India (G. Chowdhury, G.P. Pazhani, A. Sarkar, K. Rajendran, A.K. Mukhopadhyay, M.K. Bhattacharya, A. Ghosh, T. Ramamurthy); National Institute of Pharmaceutical Education and Research, Kolkata (G.P. Pazhani); Translational Health Science and Technology Institute, Faridabad, India (T. Ramamurthy)

Main Article

Table 2

Antimicrobial drug resistance profiles before and after transfer of NDM-1-–ncoding plasmid from Vibrio fluvialis strains to other bacterial species in study of diarrheal fecal samples from patients in Kolkata, India, May 2009–September 2013*

Isolate no.
Test isolate
 Resistance profile 
of wild type
 Resistance profile 
of transconjugant
 MIC IPM, μg/mL†
 Frequency of transfer
J53-Na-Azide Escherichia coli – AMP, CRO, SXT, CXM, CTX 3 8.7 × 105
BCH 04216 EAEC AMP, ERY, SXT, NA, CXM, CTX AMP, E, SXT, NA, CXM, CTX, CRO 3 5.9 × 105
IDH 04184 EPEC AMP, ERY, OFX, NOR, SXT, NA, CIP AMP, E, OFX, NOR, SXT, NA, CIP, CRO, CXM, CTX 1.5 2.7 × 105
IDH 06412 ETEC AMP, ERY, NA, SXT AMP, E, NA, SXT, CRO, CXM, CTX 3 7.5 × 105
BCH 0704 Salmonella Bareilly – AMP, CRO, SXT, CXM, CTX 3 1.7 × 103
570764 Salmonella Newport – AMP, CRO, SXT, CXM, CTX 3 1.4 × 103
IDH 06370 Shigella dysenteriae 12 AMP, STR, NA AMP, STR, NA, CRO, SXT, CXM, CTX 1.5 2.4 × 103
IDH 06498 Shigella flexneri 4 AMP, E, STR, SXT AMP, E, STR, SXT, CRO, CXM, CTX 3 4.4 × 103
IDH 06342 Shigella flexneri 1b AMP, E, NA, STR, SXT AMP, E, NA, STR, SXT, CRO, CXM, CTX 0.75 1.9 × 103
IDH 03988 V. parahaemolyticus AMP AMP, CRO, SXT, CXM, CTX 0.50 5.7 × 105

*Antibiogram in bold among transconjugants denote acquired resistance phenotypes from V. fluvialis IDH05720 after conjugation. AMP, ampicillin; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; CXM, cefuroxime; EAEC, enteroaggressive E. coli; EPEC, enteropathogenic E. coli; ERY, erythromycin; ETEC, enterotoxigenic E. coli; NA, nalidixic acid; NDM-1, New Delhi metallo-β-lactamase; NOR, norfolxacin; OFX, ofloxacin; STR, streptomycin, SXT, sulfamethoxxozole.
†MIC for imepenium. MIC denotes values of imepenium across different pathogens that were used as transconjugants.

Main Article

Page created: September 19, 2016
Page updated: September 19, 2016
Page reviewed: September 19, 2016
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