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Volume 22, Number 12—December 2016
Letter

Pathogenic Lineage of mcr-Negative Colistin-Resistant Escherichia coli, Japan, 2008–2015

Toyotaka SatoComments to Author , Akira Fukuda, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Masaru Usui, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, and Shin-ichi Yokota
Author affiliations: Sapporo Medical University School of Medicine, Sapporo, Japan (T. Sato, Y. Suzuki, T. Shiraishi, H. Honda, S. Yamamoto, N. Ogasawara, H. Takahashi, S. Takahashi, S. Yokota); Rakuno Gakuen University, Ebetsu, Japan (A. Fukuda, M. Usui, Y. Tamura); Sapporo Medical University Hospital, Sapporo (M. Shinagawa)

Main Article

Table

Characterization of colistin-resistant Escherichia coli isolates, Japan, 2008–2105*

Strain Specimen type Patient age, y/sex Year Serotype ST MIC, mg/L†
PIP CAZ CPD FEP IPM GEN AMK CIP CST PMB
SRE34
Urine catheter
UNK/F
2008
O25b:H4
131-
H30Rx
128 (R)
1 
(S)
1 
(S)
0.06 (S)
0.125 (S)
0.5 (S)
2 
(S)
32 (R)
16 (R), 16 (R)‡
8, 
8‡
SRE44
Urine catheter
UNK/M
2008
O25b:H4
131-
H30Rx
64 (R)
2 
(S)
1 
(S)
0.13 
(S)
0.25 (S)
0.5 (S)
1 
(S)
64 (R)
16 (R), 16 (R)‡
16, 
8‡
SME222
Indwelling pericardial drain
76/M
2015
O18
416
2 
(S)
0.5 (S)
0.5 (S)
<0.03 (S)
0.13 (S)
0.5 (S)
2 
(S)
0.03 (S)
4 (R), 
4 (R)‡
8, 
4‡
SME296 Urine 67/M 2015 O25b:H4 131-
H30R >128 (R) 32 (R) >128 (R) 16 (R) 0.13 (S) 0.5 (S) 2 
(S) 64 (R) 4 (R), 
8 (R)‡ 1, 
4‡

*All isolates were phylogentic group B2. AMK, amikacin; CAZ, ceftazidime; CIP, ciprofloxacin; CPD, cefpodoxime; FEP, cefepime; CST, colistin; GEN, gentamicin; IPM, imipenem; PIP, piperacillin; PMB, polymyxin B; R, resistant; S, susceptible; ST, sequence type; UNK, unknown.
†EUCAST (http://www.eucast.org/) breakpoints were used for resistance determination because the colistin breakpoint for E. coli was undetermined by the Clinical and Laboratory Standards Institute. MICs were determined by the agar dilution method unless otherwise stated. Breakpoints: PIP, >16; CAZ, >16; CPD, >1; FEP, >4; IPM, >8; GEN, >4; AMK, >16; CIP, >1; CST, >2.
‡Broth microdilution method.

Main Article

Page created: November 18, 2016
Page updated: November 18, 2016
Page reviewed: November 18, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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