TY - JOUR AU - Zorrilla-Vaca, Andrés AU - Arevalo, Jimmy AU - Escandón-Vargas, Kevin AU - Soltanifar, Daniel AU - Mirski, Marek T1 - Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014 T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 6 SP - 981 SN - 1080-6059 AB - Administration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989–2014. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. There remains a lack of comprehensive information on the effectiveness of measures to prevent future outbreaks. KW - anesthesia KW - Propofol KW - contamination KW - hospital infection KW - outbreak KW - safety KW - complication KW - public health KW - phenol KW - lipidemulsion KW - soybean KW - phosphatide KW - glycerol KW - edetate disodium KW - EDTA KW - fospropofol KW - lipophilic KW - intravenous KW - iatrogenic KW - nosocomial KW - 2 KW - 6-diisopropylphenol DO - 10.3201/eid2206.150376 UR - https://wwwnc.cdc.gov/eid/article/22/6/15-0376_article ER - End of Reference