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Volume 3, Number 3—September 1997

Perspective

Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)

Janet M. McNichollComments to Author , Dawn K. Smith, Shoukat H. Qari, and Thomas Hodge
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 1

Human chemokine receptors.

Ligands
(MCP-1Ra)
Receptors
(Old names)a C-C chemokines CXC chemokines Predominant expression/Tissue distribution Pathogensb Chromosome
location GenBank Acc. #
CC Receptors
CCR1 (CC CKR1) αβ, RANTES, MCP-3 monocytes, T cells 3p21 L10918
CCR2A MCP-1 T cells, basophils, monocytes 3p21 U03882
CCR2B (MCP-1Rb) MCP-1, 3, 4 HIV-1 (NSI) U03905
CCR3
(CKR3) Eotaxin, RANTES, MCP-2,3,4 eosinophil, basophils, microglial cells, and possibly monocytes; little expression in peripheral blood T-lymphocytes or dendritic cells HIV-1 (NSI) 3p21 U28694
CCR4 TARC basophils, T cells 3p24 X85740
CCR5c
(CC CKR5) RANTES, MIP-1αβ monocytes, dendritic cells, microglial cells, T cells HIV-1 (NSI), HIV-2 3p21 U57840
CXC Receptors
CXCR1
(IL-8 RA) IL-8 neutrophils, NK cells 2q35 M68932
CXCR2
(IL-8 RB) IL-8, MGSA, gro-α , NAP-2, IP-10, ENA-78, Mig M73969
CXCR3 IP-10, Mig activated T cells X95876
CXCR4
(Fusin, LESTR, HUMSTR) SDF-1 wide: CD4+ and CD4- cells, monocytes, macrophages, dendritic cells, B cells; other tissues, e.g., brain, lung, spleen HIV-1 (SI)
HIV-2 2q21 M99293
CC/CXC Receptor
DARC
(Duffy antigen) RANTES, MCP-1, TARC etc. IL-8, MGSA, groetc. endothelial cells, erythrocytes Plasmodium vivax 1 U01839
Othersd
STRL33 ND ND lymphoid tissues and activated T cells HIV-1 3 U73529
HCMV-US28 MIP-1αβ, RANTES fibroblasts infected with CMV HIV-1 N/A X17403
ChemR1 ND ND T lymphocytes, polymorphonuclear cells 3p21-24 Y08456
CMKBRL1 ND ND neutrophils, monocytes, brain, liver, lung, skeletal muscles 3p21 U28934
TER1 ND ND thymus, spleen 3p21 U62556
V28 ND ND Neural and lymphoid tissue 3p21 U20350
D2S201E ND ND wide, including cells of hemopoietic origin 2q21 M99293
BLR1 ND ND B lymphocytes X68149
EBI1 ND ND B lymphocytes L08176
GPR1,2,5 ND ND ND L36149

a New nomenclature for CC and CXC chemokine receptors was adopted at the Gordon Research Conference on Chemotactic Cytokines, June 23-28, 1996.
bPathogens using this receptor for infection.
cThe 32bp deleted allele of CCR5 has been referred to as CCR5-2 (19).
dChemokine receptor-like genes whose predicted proteins have 7 transmembrane domains.
Abbreviations: BLR1, Burkitt's lymphoma receptor-1; CMKBRL1, Chemokine β receptor like-1; DARC, duffy antigen/receptor for chemokines; EBI1, Epstein-Barr virus-induced receptor; ENA78, epithelial-derived neutrophil-activating peptide-78; GPR, G protein coupled receptor; gro, growth related gene product; HCMV, human cytomegalovirus; HUMSTR, human serum transmembrane segment receptor; IL, interleukin; IP-10, interferon-gamma inducible 10kD protein; LESTR, leukocyte-expressed seven-transmembrane-domain receptor; MCP, monocyte chemotactic protein; Mig, monokine induced by interferon gamma; MIP, macrophage inflammatory protein; NSI, non-syncytium inducing; N/A, not applicable; NAP-2, neutrophil-activating protein-2; ND, not determined; RANTES, regulated on activation, normal T cell expressed and secreted; SDF-1, stromal cell-derived factor-1; STRL33, seven transmembrane-domain receptor from lymphocyte clone 33; TARC, thymus and activation regulated chemokine.

Main Article

1Garred P, Eugen-Olsen J, Iversen AKN, Benfield TL, Svejgaard A, Hofmann, B, the Copenhagen AIDS Study Group. Dual effect of CCR5 D32 gene deletion in HIV-1-infected patients. Lancet 1997; 349:1884.

2Martinson JJ, Chapman NH, Rees DC, Lui Y-T, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion [letter]. Nature Genetics 1997;16:100-103.

3Centers for Disease Control and Prevention. Facts about CCR5 and protection against HIV-1 infection; 1997.

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