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Volume 3, Number 3—September 1997

Perspective

Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)

Janet M. McNichollComments to Author , Dawn K. Smith, Shoukat H. Qari, and Thomas Hodge
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 2

Population studies of CCR5 genotypes

aCCR5 Genotypes % (N)
 Author Population Ethnicity HIV Status No. W/W w/∆32 ∆32/∆32 ∆32 allele frequency (%)
Liu et al. (9) High-risk, USA Caucasian Neg 15 80.0 (12) 0 (0) 20.0 (3) 0.200
General, USA Caucasian Neg 122 80.3 (98) 19.7 (24) 0 (0) 0.098
General, S. America Venezuelan Neg 46 100 (46) 0 (0) 0 (0) 0
Samson et al. (16) General, Europe Caucasian Neg 704 82.7 (582) 16.2 (114) 1.1 (8) 0.092
General, Asia Japanese Neg 248 100 (248) 0 (0) 0 (0) 0
General, Africa Ctrl/West African Neg 124 100 (124) 0 (0) 0 (0) 0
AIDS clinics, Paris Caucasian Pos 723 89.2 (645) 10.8 (78) 0 (0) 0.054
Dean et al.b (17) High-risk, USA Mixed Neg 883 81.9 (724) 15.6 (138) 2.4 (21) 0.10
High-risk, USA Mixed Pos 1883 85.9 (1618) 14.0 (264) 0.0005 (1) 0.071
High-risk, USA African-Amer Mixed 620 96.6 (599) 3.4 (21) 0 (0) 0.017
High-risk, USA Caucasian Mixed 1250 0.115
Low-risk, USA Caucasian Mixed 143 0.080
Huang et al. (12) High-risk, USA Caucasian Pos 461 79.8 (368) 20.2 (93) 0 (0) 0.101
High-risk, USA Caucasian Neg 446 78.0 (348) 16.7 (82) 3.6 0.128
Blood donors, USA Caucasian (95%) Neg 637 85.2 13.3 1.4 0.08
General, Africa/Haiti Black Mixed 137 100 0 (0) 0 (0) 0
General, Asia China/Thai/other Mixed 191 100 0 (0) 0 (0) 0
Michael et al. (18) High-risk, USA Mixed Pos 406 87.5 (348) 14.3 (58) 0 (0) 0.071
High-risk, USA Mixed Neg 21 71.4 (15) 9.5 (2) 19.1 (4) 0.238
Intermediate-risk, USA Mixed Neg 240 78.3 (188) 20.4 (49) 1.3 (3) 0.115
Biti et al. (20) High-risk, Australia Caucasian Pos 265 N/Ac N/A 0.004 (1) N/A
Theodoru et al. (22) High-risk, Europe Pos 412 N/A N/A 0.002 (1) N/A
Eugenolsen et al. (23) High-risk, Denmark Caucasian Neg 35 74 (26) 20 (7) 6 (2) 0.157
High-risk, Denmark Caucasian Pos 99 78 (77) 22 (22) 0 0.111
Blood donors, Denmark Caucasian Neg 37 73 (27) 24 (9) 3 (1) 0.149
Zimmerman et al. (19) Blood donors, North America Caucasian Neg 387 77.5 (300) 21.7 (84) 0.8 (3) 0.116
African Amer Neg 294 94.2 (277) 5.8 (17) 0 (0) 0.29
Hispanic Neg 290 92.8 (269) 6.9 (20) 0.3 (1) 0.38
Asian Neg 164 99.4 (163) 0.6 (1) 0 (0) 0.003
Native Amer. Neg 87 83.9 (73) 12.6 (11) 3.4 (3) 0.098
Blood donors, India Tamil Neg 46 100 (46) 0 (0) 0(0) 0
Blood donors, W. Africa Black Neg 40 100 (40) 0 (0) 0 (0) 0
High Risk, USA Caucasian Pos 614 77.4 (475) 22.6 (139) 0 (0) 0.113
High Risk, USA African Amer Pos 86 97.7 (84) 2.3 (2) 0 (0) 0.012
High Risk, USA Hispanic Pos 45 93.3 (42) 6.7 (3) 0 (0) 0.033
High Risk USA Caucasian Neg 111 73.9 (82) 21.6 (24) 4.5 (5) 0.0153
High Risk, USA African Amer Neg 2 50.0 (1) 0 (0) 0.250
High Risk, USA Hispanic Neg 12 91.7 (11) 8.3 (1) 0 (0) 0.042

a CCR5 genotypes: W/W, homozygous wild type; W/∆ 32, heterozygous wild type/32bp deletion; ∆32/∆32, homozygous for the 32 bp deletion.
b Numbers updated to include additional Multicenter Hemophiulia Cohort Study patients studied by O'Brien et al. (21) and Dean et al. (pers .comm.).
cNotSUP>cNot available

Main Article

1Garred P, Eugen-Olsen J, Iversen AKN, Benfield TL, Svejgaard A, Hofmann, B, the Copenhagen AIDS Study Group. Dual effect of CCR5 D32 gene deletion in HIV-1-infected patients. Lancet 1997; 349:1884.

2Martinson JJ, Chapman NH, Rees DC, Lui Y-T, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion [letter]. Nature Genetics 1997;16:100-103.

3Centers for Disease Control and Prevention. Facts about CCR5 and protection against HIV-1 infection; 1997.

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