Emerging Infectious Disease ISSN: 1080-6059

Resistance, Remission, and Qualitative Differences in HIV Chemotherapy

Denise E. Kirschner*

and G.F. Webb

Author affiliations: *University of Michigan Medical School, Ann Arbor, Michigan, USA; and †Vanderbilt University, Nashville, Tennessee, USA

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Figure 3

Treatment simulations for four starting viral levels. The simulations have a common viral set-point of disease progression, and the treatment starting values are from Figure 1a,b. For all four simulations, the treatment parameters are c1=2.0, c2=1.0, c3=.1, the resistance mutation parameter is q=10-7, and the threshold value is V0=.5 (indicated by the horizontal line). The lowest starting viral level achieves remission (a), while the other three develop resistance.

Figure 3. Treatment simulations for four starting viral levels. The simulations have a common viral set-point of disease progression, and the treatment starting values are from Figure 1a,b. For all four simulations, the treatment parameters are c₁=2.0, c₂=1.0, c₃=.1, the resistance mutation parameter is q=10^-7, and the threshold value is V₀=.5 (indicated by the horizontal line). The lowest starting viral level achieves remission (a), while the other three develop resistance.

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