Volume 4, Number 1—March 1998
Proteases of Malaria Parasites: New Targets for Chemotherapy
|Halofantrine||TX of Pf malaria; not approved for CP||Usually effective against R Pf malaria||Variable bioavailability, cardiac toxicity|
|Artemisinin and related compoundsa||TX of Pf malaria||Rapidly acting; effective against multidrug-R strains||Recurrence after TX fairly common|
|Atovaquone||? TX of Pf malaria; ? CP (probably in combination with proguanil)||Limited toxicity||Limited studies so far show frequent recurrence after TX|
|Pyronaridinea||? TX of Pf malaria||Effective against R strains||Studies limited to date|
|Desferrioxamine||? TX of severe Pf malaria||Well tolerated when used for iron overload||Studies limited to date|
|Azithromycin||? CP||Limited toxicity||Studies limited to date|
For abbreviations, see Table 1, footnote a.
aNot available in the United States.
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