Similarity of Chemokines Charge and the V3 Domain of HIV-1 env Protein
Figure. Amino acid alignment of the four chemokines was performed with the PC/Gene program. An overall identity and similarity of 12.4% and 40.2% was calculated, respectively. The initiator methionine contained within each sequence is removed in the processing of the chemokine. The SDF-1 form shown is the ß-form; the α-form lacks the C-terminal amino acids RFKM, thus reducing the net charge to +9. * = a perfectly conserved residue; . = a conservative change.