Emerging Infectious Disease ISSN: 1080-6059

Similarity of Chemokines Charge and the V3 Domain of HIV-1 env Protein

Ben Berkhout and Atze T. Das

Author affiliations: University of Amsterdam, Amsterdam, The Netherlands;

Figure

Amino acid alignment of the four chemokines was performed with the PC/Gene program. An overall identity and similarity of 12.4% and 40.2% was calculated, respectively. The initiator methionine contained within each sequence is removed in the processing of the chemokine. The SDF-1 form shown is the ß-form; the α-form lacks the C-terminal amino acids RFKM, thus reducing the net charge to +9. * = a perfectly conserved residue; . = a conservative change.

Figure. Amino acid alignment of the four chemokines was performed with the PC/Gene program. An overall identity and similarity of 12.4% and 40.2% was calculated, respectively. The initiator methionine contained within each sequence is removed in the processing of the chemokine. The SDF-1 form shown is the ß-form; the α-form lacks the C-terminal amino acids RFKM, thus reducing the net charge to +9. * = a perfectly conserved residue; . = a conservative change.

Main Article

Top of Page

The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.