Emerging Infectious Disease ISSN: 1080-6059

Cell-to-Cell Signaling and Pseudomonas aeruginosa Infections

Christian Van Delden and Barbara H. Iglewski

Author affiliations: University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

Figure 2

Model of the different phases of Pseudomonas aeruginosa infection. After an initial colonization phase, mostly dependent on cell-associated virulence factors, the infectious process evolves either to a chronic infection characterized by low production of extracellular virulence factors or to an acute infection characterized by high production of cell-to-cell signaling dependent virulence factors. During acute exacerbation of chronic infection, the production of cell-to-cell signaling dependent v

Figure 2. Model of the different phases of Pseudomonas aeruginosa infection. After an initial colonization phase, mostly dependent on cell-associated virulence factors, the infectious process evolves either to a chronic infection characterized by low production of extracellular virulence factors or to an acute infection characterized by high production of cell-to-cell signaling dependent virulence factors. During acute exacerbation of chronic infection, the production of cell-to-cell signaling dependent virulence factors is highly increased.

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