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Volume 4, Number 4—December 1998

Synopsis

Cell-to-Cell Signaling and Pseudomonas aeruginosa Infections

Christian Van Delden and Barbara H. Iglewski
Author affiliations: University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

Main Article

Figure 4

The cell-to-cell signaling circuitry of P. aeruginosa. The las cell-to-cell signaling system controls the rhl cell-to-cell signaling system in a hierarchy cascade. The LasR/3-oxo-C12-HSL complex activates the transcription of rhlR, and 3-oxo-C12-HSL blocks the activation of RhlR by C4-HSL. The las system itself is controlled positively by Vfr and GacA, and negatively by RsaL. 3-oxo-C12-HSL is required for biofilm differentiation and has immunomodulatory activity. Both cell-to-cell signaling syst

Figure 4. The cell-to-cell signaling circuitry of P. aeruginosa. The las cell-to-cell signaling system controls the rhl cell-to-cell signaling system in a hierarchy cascade. The LasR/3-oxo-C12-HSL complex activates the transcription of rhlR, and 3-oxo-C12-HSL blocks the activation of RhlR by C4-HSL. The las system itself is controlled positively by Vfr and GacA, and negatively by RsaL. 3-oxo-C12-HSL is required for biofilm differentiation and has immunomodulatory activity. Both cell-to-cell signaling systems regulate the expression of numerous genes (lasB: LasB elastase, lasA: LasA elastase, toxA: exotoxin A, aprA: alkaline protease, xcpP and xcpR: genes of the xcp secretory pathway, rhlAB: rhamnosyltransferase required for rhamnolipid production, rpoS: stationary phase sigma factor).

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