Figure 3. Gene coding assignments and three-dimensional structure of rotavirus particles. Double-stranded RNA segments separated on polyacrylamide gel (left) code for individual proteins, which are localized in the schematic of virus particle (center) or in different protein shells of virus (right). Outer capsid proteins VP4 and VP7 are neutralization antigens, which induce neutralizing antibody; protein that makes up intermediate protein shell, VP6, is the subgroup antigen. Reprinted with permission from (4).