Emerging Infectious Disease ISSN: 1080-6059

Genetic Epidemiology of Infectious Diseases in Humans: Design of Population- Based Studies

Laurent Abel*

and Alain J. Dessein†

Author affiliations: *Institut National de la Santé et de la Recherche Médicale Unit 436, Paris, France; and †Institut National de la Santé et de la Recherche Médicale Unit 399, Marseille, France

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Figure 1

Distribution of the adjusted standardized infection intensities by Schistosoma mansoni predicted by the major gene model obtained from segregation analysis and used for linkage analysis. The frequency of allele A predisposing to high infection levels was estimated at 0.16 (70% of aa, 27% of Aa, and 3% of AA persons), and the three means (corresponding to vertical lines) were -0.43, 0.78, and 3.96 for aa, Aa, and AA persons, respectively, with a residual variance equal to 0.33.

Figure 1. Distribution of the adjusted standardized infection intensities by Schistosoma mansoni predicted by the major gene model obtained from segregation analysis and used for linkage analysis. The frequency of allele A predisposing to high infection levels was estimated at 0.16 (70% of aa, 27% of Aa, and 3% of AA persons), and the three means (corresponding to vertical lines) were -0.43, 0.78, and 3.96 for aa, Aa, and AA persons, respectively, with a residual variance equal to 0.33.

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