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Volume 5, Number 1—February 1999

Synopsis

Using Monoclonal Antibodies to Prevent Mucosal Transmission of Epidemic Infectious Diseases

Larry Zeitlin*, Richard A. Cone*†, and Kevin J. Whaley*†Comments to Author 
Author affiliations: *ReProtect, LLC, Baltimore, Maryland, USA; †The Johns Hopkins University, Baltimore, Maryland, USA

Main Article

Table 1

Examples of highly effective systemic passive immunization

Pathogen Speciesa Anti-bodyb Prevention
(%) DRSc Ref.
Viruses
Chikungunya mou p 100 (15)
Cytomegalovirus hum p 50 X (16)
Dengue mou p 100 (17)
Ebola bab p 80 (18)
Hantavirus mou m 100 (19)
Herpes simplex (genital) mou m 100 X (20)
(ocular) mou m 100 (21)
HIV mou m 100 X (22)
Hepatitis A hum p 90 (23)
Hepatitis B hum p 92 (24)
Influenza mou m 100 (25)
Lassa mon p 100 (26)
Measles mou m 100 (27)
Polio hum p 58 (28)
Rabies mou m 100 (29)
Reovirus mou m 100 (30)
Rift Valley fever ham p 100 (31)
Respiratory syncytial hum m 100 (32)
p 40 (33)
Rubella hum p 57 (34)
Varicella zoster hum p 100 (35)
Venezuelan equine 
 encephalomyelitis mou p 100 (36)
Bacteria
Borrelia burgdorferi ham p 100 (37)
Bordetella pertussis mou m 100 X (38)
Chlamydia pneumoniae mou p 100 (39)
Chl. trachomatis mou m 90 (40)
Escherichia coli rat m 100 X (41)
Francisella tularensis mou p 100 (42)
Group B Streptococcus mou m 100 X (43)
Haemophilus influenzae rat p 100 X (44)
Mycoplasma pneumoniae ham p 80 (45)
Neisseria meningitis mou m 90 X (46)
Proteus mirabilis mou m 100 X (47)
Pseudomonas aeruginosa mou p 100 X (48)
Salmonella Typhimurium mou p 100 X (49)
Shigella flexneri rab p 100 X (50)
Staphylococcus aureus rab m 100 X (51)
Streptococcus pneumoniae mou p 90 X (52)
Treponema pallidum ham p 100 (53)
Yersinia pestis mou p 100 (54)
m NRd (55)
Fungi
Candida albicans mou p > 67 X (56)
Cryptococcus neoformans mou m 70 X (57)
Parasites
Plasmodium falciparum mon p 75 X (58)
Toxoplasma gondii mou m 100 (59)

aSpecies: mou=mouse; hum=human; bab=baboon; mon=monkey; ham=hamster; rat= rat; rab=rabbit.
bAntibody: m=monoclonal; p=polyclonal.
cDRS=Drug-resistant strains reported (from Ref. 60).
dNR = not reported

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