Volume 5, Number 1—February 1999
Synopsis
Using Monoclonal Antibodies to Prevent Mucosal Transmission of Epidemic Infectious Diseases
Larry Zeitlin*, Richard A. Cone*†, and Kevin J. Whaley*†
Table 1
Examples of highly effective systemic passive immunization
| Pathogen | Speciesa | Anti-bodyb | Prevention (%) | DRSc | Ref. |
|---|---|---|---|---|---|
| Viruses | |||||
| Chikungunya | mou | p | 100 | (15) | |
| Cytomegalovirus | hum | p | 50 | X | (16) |
| Dengue | mou | p | 100 | (17) | |
| Ebola | bab | p | 80 | (18) | |
| Hantavirus | mou | m | 100 | (19) | |
| Herpes simplex (genital) | mou | m | 100 | X | (20) |
| (ocular) | mou | m | 100 | (21) | |
| HIV | mou | m | 100 | X | (22) |
| Hepatitis A | hum | p | 90 | (23) | |
| Hepatitis B | hum | p | 92 | (24) | |
| Influenza | mou | m | 100 | (25) | |
| Lassa | mon | p | 100 | (26) | |
| Measles | mou | m | 100 | (27) | |
| Polio | hum | p | 58 | (28) | |
| Rabies | mou | m | 100 | (29) | |
| Reovirus | mou | m | 100 | (30) | |
| Rift Valley fever | ham | p | 100 | (31) | |
| Respiratory syncytial | hum | m | 100 | (32) | |
| p | 40 | (33) | |||
| Rubella | hum | p | 57 | (34) | |
| Varicella zoster | hum | p | 100 | (35) | |
| Venezuelan equine encephalomyelitis | mou | p | 100 | (36) | |
| Bacteria | |||||
| Borrelia burgdorferi | ham | p | 100 | (37) | |
| Bordetella pertussis | mou | m | 100 | X | (38) |
| Chlamydia pneumoniae | mou | p | 100 | (39) | |
| Chl. trachomatis | mou | m | 90 | (40) | |
| Escherichia coli | rat | m | 100 | X | (41) |
| Francisella tularensis | mou | p | 100 | (42) | |
| Group B Streptococcus | mou | m | 100 | X | (43) |
| Haemophilus influenzae | rat | p | 100 | X | (44) |
| Mycoplasma pneumoniae | ham | p | 80 | (45) | |
| Neisseria meningitis | mou | m | 90 | X | (46) |
| Proteus mirabilis | mou | m | 100 | X | (47) |
| Pseudomonas aeruginosa | mou | p | 100 | X | (48) |
| Salmonella Typhimurium | mou | p | 100 | X | (49) |
| Shigella flexneri | rab | p | 100 | X | (50) |
| Staphylococcus aureus | rab | m | 100 | X | (51) |
| Streptococcus pneumoniae | mou | p | 90 | X | (52) |
| Treponema pallidum | ham | p | 100 | (53) | |
| Yersinia pestis | mou | p | 100 | (54) | |
| m | NRd | (55) | |||
| Fungi | |||||
| Candida albicans | mou | p | > 67 | X | (56) |
| Cryptococcus neoformans | mou | m | 70 | X | (57) |
| Parasites | |||||
| Plasmodium falciparum | mon | p | 75 | X | (58) |
| Toxoplasma gondii | mou | m | 100 | (59) |
aSpecies: mou=mouse; hum=human; bab=baboon; mon=monkey; ham=hamster; rat= rat; rab=rabbit.
bAntibody: m=monoclonal; p=polyclonal.
cDRS=Drug-resistant strains reported (from Ref. 60).
dNR = not reported
